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Literature DB >> 697344

Pharmacokinetics of gentamicin administered intratracheally to rats.

T Trnovec, J Navarová, M Kettner, M Gregusková, S Bezek, A Gajdosík, A Kyselová.

Abstract

The pharmacokinetics of intratracheally instilled and intravenously injected gentamicin were compared in the rat and analyzed by a one-compartment open model. The maximum concentration of gentamicin in plasma occurred within 10 min after intratracheal instillation. Considerable amounts of gentamicin were absorbed from lungs after intratracheal instillation, as shown by its concentrations in plasma and elimination in urine. The data suggest that the absorption of gentamicin from the pulmonary system would be sufficient to maintain therapeutic levels of this agent in plasma.

Entities: Chemical Species

Mesh：

Substances：
Gentamicins

Year: 1978 PMID： 697344 PMCID： PMC352427 DOI： 10.1128/AAC.14.2.165

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

10 in total

1. Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation.

Authors: J D Brain; D E Knudson; S P Sorokin; M A Davis
Journal: Environ Res Date: 1976-02 Impact factor: 6.498

Review 2. Morphological basis of alveolar-capillary gas exchange.

Authors: E R Weibel
Journal: Physiol Rev Date: 1973-04 Impact factor: 37.312

3. [Inhalation of gentamycin. Toxicologic and pharmacokinetic experiments in rats].

Authors: A Hofmann; W Hameister; H Wahlig
Journal: Int J Clin Pharmacol Date: 1974-10

4. Endotracheal gentamicin for the prevention of bronchial infections in patients with tracheotomy.

Authors: J Klastersky; R Cappel; J Noterman; J Snoeck; C Geuning; E Mouawad
Journal: Int J Clin Pharmacol Date: 1973-07

5. [Pharmacokinetic studies on gentamicin concentration in the sputum, serum and urine following aerosol inhalation].

Authors: H Regula; O Wieser; P Naumann; W Wundt; U Kleinhuber
Journal: Int J Clin Pharmacol Date: 1973-02

6. [The absorption of gentamycin through the bronchial tree].

Authors: H Regula; W Wundt; U Kleinhuber; O Wieser
Journal: Munch Med Wochenschr Date: 1972-05-26

7. Correlation of serum creatinine concentration and gentamicin half-life.

Authors: R E Cutler; A M Gyselynck; W P Fleet; A W Forrey
Journal: JAMA Date: 1972-02-21 Impact factor: 56.272

8. [Gentamicin concentrations in tissues and body fluids of various animals].

Authors: H Wahlig; A Metallinos; W Hameister; R Bergmann
Journal: Int J Clin Pharmacol Date: 1974-10

9. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats.

Authors: J Fabre; M Rudhardt; P Blanchard; C Regamey
Journal: Kidney Int Date: 1976-12 Impact factor: 10.612

10. [Pharmacokinetic effect of various antibiotics in the tissues].

Authors: P Blanchard; M Rudhardt; J Fabre; M Leski
Journal: Schweiz Med Wochenschr Date: 1977-04-30