Literature DB >> 6972839

Immune responses of rats chronically fed subclinical doses of lead.

A Bendich, E H Belisle, H R Strausser.   

Abstract

The effects of chronic feeding of low levels of lead on various cells of the rat immune system have been investigated. In the presence of Con A and PHA, lead appears to increase blastogenesis up to approximately 5 weeks with activity approaching that of the unleaded control cells at 14 weeks. B cells responded with increased mitogenicity in the presence of LPS up to the time of termination of the experiment (14 weeks). Macrophage activity and number in the lead-fed rat showed consistent decrease and eventual morphological impairment. It is hypothesized that lead has mitogen-like activity but disruption of macrophage-T cell interaction occurs with time.

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Year:  1981        PMID： 6972839      PMCID： PMC1537135     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  16 in total

1.  Humoral antibody response in mice after single dose exposure to lead or cadmium.

Authors:  L D Koller; J H Exon; J G Roan
Journal:  Proc Soc Exp Biol Med       Date:  1976-02

2.  Decreased antibody formation in mice exposed to lead.

Authors:  L D Koller; S Kovacic
Journal:  Nature       Date:  1974-07-12       Impact factor: 49.962

3.  Reticuloendothelial and hepatic functional alterations following lead acetate administration.

Authors:  R A Trejo; N R Di Luzio; L D Loose; E Hoffman
Journal:  Exp Mol Pathol       Date:  1972-10       Impact factor: 3.362

4.  Renal ultrastructure, renal function, and parameters of lead toxicity in workers with different periods of lead exposure.

Authors:  K Cramér; R A Goyer; R Jagenburg; M H Wilson
Journal:  Br J Ind Med       Date:  1974-04

5.  Immunosuppression produced by lead, cadmium, and mercury.

Authors:  L D Koller
Journal:  Am J Vet Res       Date:  1973-11       Impact factor: 1.156

6.  Environmentally induced changes in immunological function: acute and chronic effects of inhalation of tobacco smoke and other atmospheric contaminants in man and experimental animals.

Authors:  P G Holt; D Keast
Journal:  Bacteriol Rev       Date:  1977-03

7.  Alveolar macrophages: reduced number in rats after prolonged inhalation of lead sesquioxide.

Authors:  E Bingham; E A Pfitzer; W Barkley; E P Radford
Journal:  Science       Date:  1968-12-13       Impact factor: 47.728

8.  Effect of lead acetate on the susceptibility of rats to bacterial endotoxins.

Authors:  H Selye; B Tuchweber; L Bertók
Journal:  J Bacteriol       Date:  1966-02       Impact factor: 3.490

9.  Lead suppression of mouse resistance to Salmonella typhimurium.

Authors:  F E Hemphill; M L Kaeberle; W B Buck
Journal:  Science       Date:  1971-06-04       Impact factor: 47.728

10.  Developmental and behavioral changes in the rat during chronic exposure to lead.

Authors:  L W Reiter; G E Anderson; J W Laskey; D F Cahill
Journal:  Environ Health Perspect       Date:  1975-12       Impact factor: 9.031
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  3 in total

1.  Environmental cigarette smoke exposure modulates IgE levels of Pb-exposed children.

Authors:  Paula M Lutz; Elizabeth A Kelty; Tina D Brown; Terry J Wilson; Guy Brock; Rachel E Neal
Journal:  Toxicology       Date:  2011-10-25       Impact factor: 4.221

2.  Immunological effects of native and polyethylene glycol-modified asparaginases from Vibrio succinogenes and Escherichia coli in normal and tumour-bearing mice.

Authors:  A Bendich; D Kafkewitz; A Abuchowski; F F Davis
Journal:  Clin Exp Immunol       Date:  1982-04       Impact factor: 4.330

3.  Immunity in children with exposure to environmental lead: II. Effects on humoral immunity.

Authors:  P M Lutz; S Bauer; N L Gale; J Hewett; P E Phillips; F M Looney; H Bengsch
Journal:  Environ Geochem Health       Date:  1994-12       Impact factor: 4.609
  3 in total

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