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Literature DB >> 6969156

The effect of the plant lectins phytohaemagglutinin and concanavalin A on human T cell populations bearing receptors for IgG and IgM.

Abstract

The effect of long-term culture with the plant lectins phytohaemagglutinin (PHA) and concanavalin A (con A) on the percentages of human T cells bearing Fc receptors for IgG (TG) and IgM (TM) was investigated. Con A produced an early increase in the percentage of TG cells as compared to control cells cultured without mitogen. TM cells decreased. PHA suppressed the percentages of both TG and TM. These changes were not due to loss of cell viability nor to loss of cell surface receptors in general since up to 98% of the cells continued to form sheep erythrocyte rosettes in the virtual absence of IgM Fc receptors.

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Year: 1980 PMID： 6969156 PMCID： PMC1537020

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

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References

22 in total

Review 1. Subpopulations of T-lymphocytes. Physical separation, functional specialisation and differentiation pathways of sub-sets of thymocytes and thymus-dependent peripheral lymphocytes.

Authors: K Shortman; H Von Boehmer; J Lipp; K Hopper
Journal: Transplant Rev Date: 1975

9. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

Authors: H Cantor; E A Boyse
Journal: J Exp Med Date: 1975-06-01 Impact factor: 14.307

10. Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. II. Evidence for separate stimulatory and inhibitory cells.

Authors: R W Dutton
Journal: J Exp Med Date: 1973-12-01 Impact factor: 14.307

The effect of the plant lectins phytohaemagglutinin and concanavalin A on human T cell populations bearing receptors for IgG and IgM.

Review 1. Subpopulations of T-lymphocytes. Physical separation, functional specialisation and differentiation pathways of sub-sets of thymocytes and thymus-dependent peripheral lymphocytes.

2. An improved technique for obtaining E rosettes with human lymphocytes and its use for B cell purification.

3. Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells.

4. Expression of a receptor for IgM by human T cells in vitro.

5. An improved rosetting assay for detection of human T lymphocytes.

6. Ly antigens: markers of T cell function on mouse spleen cells.

Review 7. Development and function of subpopulations of thymocytes and T lymphocytes.

8. Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness.

9. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

10. Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. II. Evidence for separate stimulatory and inhibitory cells.