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Literature DB >> 4543456

Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. II. Evidence for separate stimulatory and inhibitory cells.

Abstract

The addition of concanavalin A to mouse spleen cell suspensions can either inhibit or stimulate the immune response to heterologous erythrocytes according to the experimental conditions. Evidence is presented which is incompatible with the hypothesis that these two effects are mediated by a single cell and which favors the hypothesis of separate inhibitor and stimulatory cells.

Entities: CellLine Species

Mesh：

Substances：
Concanavalin A

Year: 1973 PMID： 4543456 PMCID： PMC2139467 DOI： 10.1084/jem.138.6.1496

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

11 in total

1. Activation of B lymphocytes by locally concentrated concanavalin A.

Authors: J Andersson; G M Edelman; G Möller; O Sjöberg
Journal: Eur J Immunol Date: 1972-06 Impact factor: 5.532

Review 2. Phytohemagglutin and concanavalin A: probes for murine 'T' cell activivation and differentiation.

Authors: J D Stobo
Journal: Transplant Rev Date: 1972

3. Replacement of T-cell function by a T-cell product.

Authors: A Schimpl; E Wecker
Journal: Nat New Biol Date: 1972-05-03

4. Initiation of antibody production to sheep erythrocytes in vitro: replacement of the requirement for T-cells with a cell-free factor isolated from cultures of lymphoid cells.

Authors: R M Gorczynski; R G Miller; R A Phillips
Journal: J Immunol Date: 1972-02 Impact factor: 5.422

5. 'Nude', a new hairless gene with pleiotropic effects in the mouse.

Authors: S P Flanagan
Journal: Genet Res Date: 1966-12 Impact factor: 1.588

6. Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes.

Authors: R R Rich; C W Pierce
Journal: J Exp Med Date: 1973-03-01 Impact factor: 14.307

7. Immunization of dissociated spleen cell cultures from normal mice.

Authors: R I Mishell; R W Dutton
Journal: J Exp Med Date: 1967-09-01 Impact factor: 14.307

8. Biological expressions of lymphocyte activation : I. Effects of phytomitogens on antibody synthesis in vitro.

Authors: R R Rich; C W Pierce
Journal: J Exp Med Date: 1973-01-31 Impact factor: 14.307

9. Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).

Authors: I Gery; B H Waksman
Journal: J Exp Med Date: 1972-07-01 Impact factor: 14.307

10. Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. I. Characterization of the inhibitory cell activity.

Authors: R W Dutton
Journal: J Exp Med Date: 1972-12-01 Impact factor: 14.307

36 in total

1. Inhibition of humoral and cell-mediated immune responses in man by distinct suppressor cell systems.

Authors: P I Lobo; C E Spencer
Journal: J Clin Invest Date: 1979-06 Impact factor: 14.808

2. Dual response of lymphocytes from multiple sclerosis patients to myelin basic protein.

Authors: V Wicher; W Olszewski; F Milgrom
Journal: Clin Exp Immunol Date: 1979-07 Impact factor: 4.330

3. Separation of helper and suppressor T lymphocytes. II. Ly phenotypes and lack of DNA synthesis requirement for the generation of concanavalin A helper and suppressor cells.

Authors: H Y Tse; R W Dutton
Journal: J Exp Med Date: 1977-09-01 Impact factor: 14.307

4. In vitro induction of a contrasuppressor immunoregulatory network by polyclonally activated T cells derived from murine Peyer's patches.

Authors: H Kawanishi; J Kiely
Journal: Immunology Date: 1988-03 Impact factor: 7.397

5. Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody.

Authors: J Sharon; M L Gefter; T Manser; M Ptashne
Journal: Proc Natl Acad Sci U S A Date: 1986-04 Impact factor: 11.205

9. Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold.

Authors: J Sharon
Journal: Proc Natl Acad Sci U S A Date: 1990-06 Impact factor: 11.205

10. Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis.

Authors: D A Hume; K Wrogemann; E Ferber; M E Kolbuch-Braddon; R M Taylor; H Fischer; M J Weidemann
Journal: Biochem J Date: 1981-09-15 Impact factor: 3.857