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Literature DB >> 6968555

Characteristics and drug responses of cochlear and vestibular adenylate cyclase.

D Bagger-Sjöbäck, C S Filipek, J Schacht.

Abstract

Adenylate cyclase activity of dissected cochlear and vestibular structures was assayed with the ATP-analog adenylyl imidodiphosphate as substrate. High activities (per mg protein) were found in stria vascularis and in vestibular preparations, lower activities in spiral ligament, VIIIth nerve, and organ of Corti. The enzyme from all structures was stimulated by fluoride, guanylyl imidodiphasphate or manganese(II) ions, and strongly inhibited by ethacrynate and lead ion. The anti-cancer drug cis-diammine-dichloro platinum significantly inhibited adenylate cyclase from stria vascularis.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1980 PMID： 6968555 DOI： 10.1007/BF00454231

Source DB: PubMed Journal: Arch Otorhinolaryngol ISSN： 0302-9530

12 in total

1. Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig.

Authors: R W Fleischman; S W Stadnicki; M F Ethier; U Schaeppi
Journal: Toxicol Appl Pharmacol Date: 1975-08 Impact factor: 4.219

2. Cyclic AMP and adenylate cyclase in the inner ear.

Authors: P Ahlström; I Thalmann; R Thalmann; I Ise
Journal: Laryngoscope Date: 1975-07 Impact factor: 3.325

3. Actions of "loop" diuretics and mercurials upon the cochlea.

Authors: R Thalmann; I Ise; B A Bohne; I Thalmann
Journal: Acta Otolaryngol Date: 1977 Jan-Feb Impact factor: 1.494

4. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

5. Effects of Mn2+ and other divalent cations on adenylate cyclase activity in rat brain.

Authors: K G Walton; R J Baldessarini
Journal: J Neurochem Date: 1976-08 Impact factor: 5.372

Review 6. Role of cyclic nucleotides in the transport of water and electrolytes.

Authors: G J Strewler; J Orloff
Journal: Adv Cyclic Nucleotide Res Date: 1977

7. Adenylate cyclase assay with adenylyl imidodiphosphate and product detection by competitive protein binding.

Authors: M E Maguire; A G Gilman
Journal: Biochim Biophys Acta Date: 1974-07-17

8. Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man.

Authors: I J Piel; D Meyer; C P Perlia; V I Wolfe
Journal: Cancer Chemother Rep Date: 1974 Nov-Dec

9. Vasopressin and isoproterenol activate adenylate cyclase in the guinea pig inner ear.

Authors: H P Zenner; B Zenner
Journal: Arch Otorhinolaryngol Date: 1979

10. Cis-dichlorodiammineplatinum (II) (NSC-119875): hearing loss and other toxic effects in rhesus monkeys.

Authors: S W Stadnicki; R W Fleischman; U Schaeppi; P Merriam
Journal: Cancer Chemother Rep Date: 1975 May-Jun

15 in total

1. Adenylate cyclase and carbonic anhydrase in the semicircular canal epithelium of the frog Rana esculenta. An ultrastructural cytochemical localization.

Authors: O Oudar; E Ferrary; G Feldmann
Journal: Cell Tissue Res Date: 1990-12 Impact factor: 5.249

2. Inhibition of adenylate-cyclase-coupled G protein complex by ototoxic diuretics and cis-platinum in the inner ear of the guinea pig.

Authors: T Koch; B Gloddek
Journal: Eur Arch Otorhinolaryngol Date: 1991 Impact factor: 2.503

Characteristics and drug responses of cochlear and vestibular adenylate cyclase.

1. Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig.

2. Cyclic AMP and adenylate cyclase in the inner ear.

3. Actions of "loop" diuretics and mercurials upon the cochlea.

4. Protein measurement with the Folin phenol reagent.

5. Effects of Mn2+ and other divalent cations on adenylate cyclase activity in rat brain.

Review 6. Role of cyclic nucleotides in the transport of water and electrolytes.

7. Adenylate cyclase assay with adenylyl imidodiphosphate and product detection by competitive protein binding.

8. Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man.

9. Vasopressin and isoproterenol activate adenylate cyclase in the guinea pig inner ear.

10. Cis-dichlorodiammineplatinum (II) (NSC-119875): hearing loss and other toxic effects in rhesus monkeys.

1. Adenylate cyclase and carbonic anhydrase in the semicircular canal epithelium of the frog Rana esculenta. An ultrastructural cytochemical localization.

2. Inhibition of adenylate-cyclase-coupled G protein complex by ototoxic diuretics and cis-platinum in the inner ear of the guinea pig.

3. Comparative acute ototoxicity of loop diuretic compounds.

4. Is intratympanic injection of erdosteine protective against cisplatin-induced ototoxicity?

5. The effect of adenylate cyclase stimulation on endocochlear potential in the guinea pig.

6. Adenylate cyclase and G-proteins as a signal transfer system in the guinea pig inner ear.

7. Antidiuretic hormone stimulation of adenylate cyclase in semicircular canal epithelium.

8. The importance of high-tone audiometry in monitoring for ototoxicity.

9. Changes in the stria vascularis of the guinea pig due to cis-platinum.

10. Biochemical studies on the embryonic development of the mammalian inner ear in organ culture.