| Literature DB >> 69670 |
F M Davenport, A V Hennessy, H F Maassab, E Minuse, L C Clark, G D Abrams, J R Mitchell.
Abstract
Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.Entities:
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Year: 1977 PMID： 69670 DOI： 10.1093/infdis/136.1.17
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226