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Literature DB >> 6965109

Enhanced internalization of ricin in nigericin-pretreated Chinese hamster ovary cells.

Abstract

Biochemical and electron microscopic autoradiographic studies with [125I] ricin have revealed that nigericin-pretreated Chinese hamster ovary cells are more efficient than untreated cells in the internalization of the toxin into the cells. These results suggest that the enhanced rate of internalization of ricin in nigericin-pretreated cells may account for the enhancement of cytotoxicity of ricin in Chinese hamster ovary cells by nigericin.

Entities: Chemical Disease Species

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Year: 1981 PMID： 6965109 PMCID： PMC369699 DOI： 10.1128/mcb.1.6.560-567.1981

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

10 in total

1. Differential chemical protection of mammalian cells from the exotoxins of Corynebacterium diphtheriae and Pseudomonas aeruginosa.

Authors: J L Middlebrook; R B Dorland
Journal: Infect Immun Date: 1977-04 Impact factor: 3.441

2. Mechanism of cell entry and toxicity of an affinity- purified lectin from Ricinus communis and its differential effects on normal and virus-transformed fibroblasts.

Authors: G L Nicolson; M Lacorbiere; T R Hunter
Journal: Cancer Res Date: 1975-01 Impact factor: 12.701

3. Internalization of neuronal plasma membrane ricin receptors into the Golgi apparatus.

Authors: N K Gonatas; A Steiber; S U Kim; D I Graham; S Avrameas
Journal: Exp Cell Res Date: 1975-09 Impact factor: 3.905

4. Properties of graphical representations of multiple classes of binding sites.

Authors: I M Klotz; D L Hunston
Journal: Biochemistry Date: 1971-08-03 Impact factor: 3.162

5. Studies on the structure and properties of the lectins from Abrus precatorius and Ricinus communis.

Authors: S Olsnes; K Refsnes; T B Christensen; A Pihl
Journal: Biochim Biophys Acta Date: 1975-09-09

6. Binding of ricin A chain to rat liver ribosomes: relationship to ribosome inactivation.

Authors: M L Hedblom; D B Cawley; S Boguslawski; L L Houston
Journal: J Supramol Struct Date: 1978

7. Effects of phagocytosis and colchicine on the distribution of lectin-binding sites on cell surfaces.

Authors: J M Oliver; T E Ukena; R D Berlin
Journal: Proc Natl Acad Sci U S A Date: 1974-02 Impact factor: 11.205

8. Internalization of ricin in Chinese hamster ovary cells.

Authors: B Ray; H C Wu
Journal: Mol Cell Biol Date: 1981-06 Impact factor: 4.272

9. Resolution in electron microscope autoradiography. III. Iodine-125, the effect of heavy metal staining, and a reassessment of critical parameters.

Authors: M M Salpeter; H C Fertuck; E E Salpeter
Journal: J Cell Biol Date: 1977-01 Impact factor: 10.539

10. Enhancement of cytotoxicities of ricin and Pseudomonas toxin in Chinese hamster ovary cells by nigericin.

Authors: B Ray; H C Wu
Journal: Mol Cell Biol Date: 1981-06 Impact factor: 5.069

10 in total

6 in total

1. Osmotically induced microinjection of ricin bypasses a ricin internalization defect in a Chinese hamster ovary mutant cell line.

Authors: P C Ghosh; R B Wellner; H C Wu
Journal: Mol Cell Biol Date: 1984-07 Impact factor: 4.272