Literature DB >> 6959112

Expression of the alpha subunit of human chorionic gonadotropin is specifically correlated with tumorigenic expression in human cell hybrids.

E J Stanbridge, S W Rosen, H H Sussman.   

Abstract

The expression of HeLa parent phenotype protein markers, the alpha subunit of human chorionic gonadotropin and placental alkaline phosphatase isoenzymes, has been evaluated in paired tumorigenic and nontumorigenic HeLa-fibroblast human cell hybrids. Both of these proteins have been used clinically as markers of malignancy. The results showed that both are expressed in the hybrids. Expression of the gonadotropin subunit in the hybrids is specifically correlated with tumorigenicity; the placental alkaline phosphatase isoenzyme showed no such correlation and was expressed in both tumorigenic and nontumorigenic hybrids.

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Year:  1982        PMID： 6959112      PMCID： PMC347096          DOI： 10.1073/pnas.79.20.6242

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Genetic control of tumorigenicity in interspecific mammalian cell hybrids.

Authors:  R Kucherlapati; S I Shin
Journal:  Cell       Date:  1979-03       Impact factor: 41.582

2.  Human alkaline phosphatase. Immunochemical identification of organ-specific isoenzymes.

Authors:  H H Sussman; P A Small; E Cotlove
Journal:  J Biol Chem       Date:  1968-01-10       Impact factor: 5.157

3.  Expression of liver and placental alkaline phosphatases in Chang liver cells.

Authors:  M A Ludueña; G M Iverson; H H Sussman
Journal:  J Cell Physiol       Date:  1977-04       Impact factor: 6.384

Review 4.  Gonadotropins and their subunits: basic and clinical studies.

Authors:  J L Vaitukaitis; G T Ross; G D Braunstein; P L Rayford
Journal:  Recent Prog Horm Res       Date:  1976

5.  A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses.

Authors:  W C Russell; C Newman; D H Williamson
Journal:  Nature       Date:  1975-02-06       Impact factor: 49.962

6.  Is somatic mutation the major mechanism of malignant transformation?

Authors:  H Rubin
Journal:  J Natl Cancer Inst       Date:  1980-05       Impact factor: 13.506

7.  Independent expression of alpha-HCG and placental alkaline phosphatase in clonal human cell lines.

Authors:  T A Hamilton; A W Tin; H H Sussman; B D Weintraub; S W Rosen
Journal:  Oncodev Biol Med       Date:  1980

8.  Alterations in the extracellular matrix organization associated with the reexpression of tumorigenicity in human cell hybrids.

Authors:  C J Der; E J Stanbridge
Journal:  Int J Cancer       Date:  1980-10-15       Impact factor: 7.396

9.  Growth-regulatory control of human cell hybrids in nude mice.

Authors:  E J Stanbridge; R Ceredig
Journal:  Cancer Res       Date:  1981-02       Impact factor: 12.701

10.  Alkaline phosphatase phenotypes in tumour and non-tumour cell lines: not an invariable marker for neoplastic transformation.

Authors:  P D Wilson; F Benham; L M Franks
Journal:  Cell Biol Int Rep       Date:  1977-05
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  8 in total

1.  Human chorionic gonadotropin in gastric carcinoma. An immunohistochemical study suggesting independent regulation of subunits.

Authors:  M Fukayama; Y Hayashi; M Koike
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1987

2.  Segregation patterns of polymorphic restriction sites of the gene encoding the alpha subunit of human chorionic gonadotropin in trophoblastic disease.

Authors:  M Hoshina; M R Boothby; R D Hussa; R A Pattillo; H M Camel; I Boime
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

Review 3.  Onc genes and other new targets for cancer chemotherapy.

Authors:  H Busch
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

Review 4.  Molecular lesions in cancer.

Authors:  H Busch
Journal:  Mol Cell Biochem       Date:  1984       Impact factor: 3.396

5.  Expression of human choriogonadotropin-like material in coagulase-negative Staphylococcus species.

Authors:  H F Acevedo; E Campbell-Acevedo; W E Kloos
Journal:  Infect Immun       Date:  1985-12       Impact factor: 3.441

6.  Identification of the HeLa tumor-associated antigen, p75/150, as intestinal alkaline phosphatase and evidence for its transcriptional regulation.

Authors:  K M Latham; E J Stanbridge
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

7.  Independent regulation by sodium butyrate of gonadotropin alpha gene expression and cell cycle progression in HeLa cells.

Authors:  R B Darnell
Journal:  Mol Cell Biol       Date:  1984-05       Impact factor: 4.272

8.  Mechanism of benzo(a)pyrene induction of alpha-human chorionic gonadotropin gene expression in human lung tumor cells.

Authors:  D T Wong; D K Biswas
Journal:  J Cell Biol       Date:  1985-12       Impact factor: 10.539
  8 in total

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