Literature DB >> 608181

Alkaline phosphatase phenotypes in tumour and non-tumour cell lines: not an invariable marker for neoplastic transformation.

P D Wilson, F Benham, L M Franks.   

Abstract

The cytochemical localisation and presumed isoenzyme type (based on selective inhibition experiments) of alkaline phosphatase in 5 cell lines derived frrom normal human, rat, mouse and hamster tissues, 6 human lymphoblastoid lines and 6 human and mouse tumour-derived cell lines are described. Enzyme activity varied between the cell lines. An isoenzyme inhibited by L-phenylalanine was present in 3 normal lines, 3 lymphoblastoid lines and 2 tumour lines. The presence of this isoenzyme cannot be used as a marker of neoplastic transformation.

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Year:  1977        PMID： 608181     DOI： 10.1016/0309-1651(77)90047-9

Source DB:  PubMed          Journal:  Cell Biol Int Rep        ISSN： 0309-1651


  4 in total

1.  Expression of the alpha subunit of human chorionic gonadotropin is specifically correlated with tumorigenic expression in human cell hybrids.

Authors:  E J Stanbridge; S W Rosen; H H Sussman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-10       Impact factor: 11.205

Review 2.  Invasiveness of transformed bladder epithelial cells.

Authors:  J F Kieler
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

3.  Cytochemical markers of bladder carcinogenesis.

Authors:  P D Wilson; I C Summerhayes; G M Hodges; L K Trejdosiewicz; W J Nathrath
Journal:  Histochem J       Date:  1981-11

4.  The ultrastructural localization of human neutrophil alkaline phosphatase in normal individuals during pregnancy and in patients with chronic granulocytic leukaemia.

Authors:  P D Wilson; G J Rustin; T J Peters
Journal:  Histochem J       Date:  1981-01
  4 in total

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