Literature DB >> 6957163

Comparison of enzymatic and liquid chromatographic chloramphenicol assays.

A F Weber, K E Opheim, J R Koup, A L Smith.   

Abstract

A radioenzymatic assay and a "high-performance" liquid chromatographic assay for chloramphenicol were compared by using 52 patient specimens, 24 mock unknowns, and 13 quality control samples. Both methods were found to be rapid, precise, accurate, and sensitive, and either would be suitable for monitoring chloramphenicol concentrations in small volumes of serum. Linear regression analysis of serum chloramphenicol concentrations in patients receiving chloramphenicol succinate yielded a regression equation of Y = 1.04X + 0.274 (X = high-performance liquid chromatographic assay; Y = radioenzymatic assay), with a correlation coefficient of 0.971.

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Year:  1981        PMID： 6957163      PMCID： PMC181419          DOI： 10.1128/AAC.19.2.323

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Gas chromatographic determination and gas chromatographic-mass sepectrometric analysis of chloramphenicol, thiamphenicol and their metabolites.

Authors:  T Nakagawa; M Masada; T Uno
Journal:  J Chromatogr       Date:  1975-09-03

2.  Simplified radioenzymatic assay for chloramphenicol.

Authors:  L R Robison; R Seligsohn; S A Lerner
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

3.  Nonspecificity of published assays for chloramphenicol solutions.

Authors:  E F Schwarm; C Dabner; J W Wilson; M P Boghosian
Journal:  J Pharm Sci       Date:  1966-07       Impact factor: 3.534

4.  Micro-scale method for liquid-chromatographic determination of chloramphenicol in serum.

Authors:  S H Petersdorf; V A Raisys; K E Opheim
Journal:  Clin Chem       Date:  1979-07       Impact factor: 8.327

Review 5.  Chloramphenicol and the neonate--1979 view.

Authors:  P S Lietman
Journal:  Clin Perinatol       Date:  1979-03       Impact factor: 3.430

6.  Rapid microbiological assay for chloramphenicol and tetracyclines.

Authors:  T J Louie; F P Tally; J G Bartlett; S L Gorbach
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191
  6 in total
  2 in total

Review 1.  Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate.

Authors:  P J Ambrose
Journal:  Clin Pharmacokinet       Date:  1984 May-Jun       Impact factor: 6.447

2.  A permeability barrier as a mechanism of chloramphenicol resistance in Haemophilus influenzae.

Authors:  J L Burns; P M Mendelman; J Levy; T L Stull; A L Smith
Journal:  Antimicrob Agents Chemother       Date:  1985-01       Impact factor: 5.191
  2 in total

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