Literature DB >> 6953431

Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver.

Y Fujii-Kuriyama, Y Mizukami, K Kawajiri, K Sogawa, M Muramatsu.   

Abstract

We determined the coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 mRNA of the rat by analysis of three cloned cDNAs and by primer extension methods. The deduced amino acid sequence of the cytochrome is composed of 491 amino acids, and its predicted molecular weight and amino acid composition concur with those determined with the purified protein. The sequence of one of the three cloned cDNAs is not identical with that of the other two. In their 922 overlapping nucleotides, 14 nucleotide substitutions occur, and 7 of them result in 6 amino acid changes, therefore indicating the presence of at least two similar but distinct mRNAs for phenobarbital-inducible cytochrome P-450. These substitutions occur in a limited portion of the sequence, apparently forming some sort of a "variable region."

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Year:  1982        PMID： 6953431      PMCID： PMC346292          DOI： 10.1073/pnas.79.9.2793

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

1.  Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

Authors:  M Grunstein; D S Hogness
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

Review 2.  Chemical carcinogenesis.

Authors:  C Heidelberger
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

3.  Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholanthrene.

Authors:  L H Botelho; D E Ryan; W Levin
Journal:  J Biol Chem       Date:  1979-07-10       Impact factor: 5.157

4.  Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis.

Authors:  T Maniatis; A Jeffrey; H van deSande
Journal:  Biochemistry       Date:  1975-08-26       Impact factor: 3.162

5.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

6.  Structural resemblance of cytochrome P-450 isolated from Pseudomonas putida and from rabbit liver microsomes.

Authors:  K Dus; W J Litchfield; A G Miguel; T A van der Hoeven; D A Haugen; W L Dean; M J Coon
Journal:  Biochem Biophys Res Commun       Date:  1974-09-09       Impact factor: 3.575

7.  The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.

Authors:  S Nagata; N Mantei; C Weissmann
Journal:  Nature       Date:  1980-10-02       Impact factor: 49.962

8.  Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover.

Authors:  I Hanukoglu; V Spitsberg; J A Bumpus; K M Dus; C R Jefcoate
Journal:  J Biol Chem       Date:  1981-05-10       Impact factor: 5.157

9.  Purification and partial characterization of hepatic microsomal cytochrome P-450s from phenobarbital- and 3-methylcholanthrene-treated rats.

Authors:  R Masuda-Mikawa; Y Fujii-Kuriyama; M Negishi; Y Tashiro
Journal:  J Biochem       Date:  1979-11       Impact factor: 3.387

10.  Construction and identification of a hybrid plasmid containing DNA sequence complementary to phenobarbital-inducible cytochrome P-450 messenger RNA from rat liver.

Authors:  Y Fujii-Kuriyama; T Taniguchi; Y Mizukami; M Sakai; Y Tashiro; M Muramatsu
Journal:  J Biochem       Date:  1981-06       Impact factor: 3.387
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  45 in total

1.  The sequence homologies of cytochromes P-450 and active-site geometries.

Authors:  D F Lewis; H Moereels
Journal:  J Comput Aided Mol Des       Date:  1992-06       Impact factor: 3.686

Review 2.  Phosphorylation of cytochrome P450 isoenzymes in intact hepatocytes and its importance for their function in metabolic processes.

Authors:  B Oesch-Bartlomowicz; F Oesch
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

3.  Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10.

Authors:  R R Meehan; J R Gosden; D Rout; N D Hastie; T Friedberg; M Adesnik; R Buckland; V van Heyningen; J Fletcher; N K Spurr
Journal:  Am J Hum Genet       Date:  1988-01       Impact factor: 11.025

4.  A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.

Authors:  Y Emi; C Chijiiwa; T Omura
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

Review 5.  The cytochrome P450 gene superfamily.

Authors:  A J Paine
Journal:  Int J Exp Pathol       Date:  1991-06       Impact factor: 1.925

6.  Inter-relatedness of some isoenzymes of cytochrome P-450 from rat, rabbit and human, determined with monoclonal antibodies.

Authors:  D Sesardic; A R Boobis; J McQuade; S Baker; E A Lock; C R Elcombe; R T Robson; C Hayward; D S Davies
Journal:  Biochem J       Date:  1986-06-01       Impact factor: 3.857

7.  Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes.

Authors:  G E Tarr; S D Black; V S Fujita; M J Coon
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

8.  Identification and localization of amino acid substitutions between two phenobarbital-inducible rat hepatic microsomal cytochromes P-450 by micro sequence analyses.

Authors:  P M Yuan; D E Ryan; W Levin; J E Shively
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

9.  At least six forms of extremely homologous cytochromes P-450 in rat liver are encoded at two closely linked genetic loci.

Authors:  A Rampersaud; F G Walz
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

10.  Mouse cytochrome P3-450: complete cDNA and amino acid sequence.

Authors:  S Kimura; F J Gonzalez; D W Nebert
Journal:  Nucleic Acids Res       Date:  1984-03-26       Impact factor: 16.971
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