Literature DB >> 6953409

Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.

K Tatemoto.   

Abstract

A new candidate hormone--designated peptide YY (PYY)--has been isolated from extracts of porcine upper intestinal tissue by using a novel chemical assay method. This peptide has been detected in the extracts by the presence of its unusual COOH-terminal tyrosine amide structure. The peptide consists of a linear chain of 36 amino acids and its complete amino acid sequence is: Tyr-Pro-Ala-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Ser-Arg-Tyr -Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2. This peptide has a distinct sequence homology to the pancreatic polypeptide. It is therefore proposed that PYY and the pancreatic polypeptide together form a new peptide family. PYY has been found to strongly inhibit both secretin- and cholecystokinin-stimulated pancreatic secretion in the anesthetized cat.

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Year:  1982        PMID： 6953409      PMCID： PMC346229          DOI： 10.1073/pnas.79.8.2514

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

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Authors:  B S Hartley
Journal:  Biochem J       Date:  1970-10       Impact factor: 3.857

2.  Structure of porcine cholecystokinin-pancreozymin. 1. Cleavage with thrombin and with trypsin.

Authors:  V Mutt; J E Jorpes
Journal:  Eur J Biochem       Date:  1968-10-17

3.  The sequence determination of a protein in a micro scale: the sequence analysis of ribosomal protein L34 of Escherichia coli.

Authors:  R Chen
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1976-06

4.  On the biological assay of secretin. The reference standard.

Authors:  J E Jorpes; V Mutt
Journal:  Acta Physiol Scand       Date:  1966-03

5.  Isolation and characterization of a new pancreatic polypeptide hormone.

Authors:  J R Kimmel; L J Hayden; H G Pollock
Journal:  J Biol Chem       Date:  1975-12-25       Impact factor: 5.157

6.  Pancreatic polypeptide. Metabolism and effect on pancreatic secretion in dogs.

Authors:  I L Taylor; T E Solomon; J H Walsh; M I Grossman
Journal:  Gastroenterology       Date:  1979-03       Impact factor: 22.682

7.  Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa.

Authors:  A A Harper; A J Hood; J Mushens; J R Smy
Journal:  J Physiol       Date:  1979-07       Impact factor: 5.182

8.  Chemical determination of polypeptide hormones.

Authors:  K Tatemoto; V Mutt
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

9.  Bovine pancreatic peptide: action on gastric and pancreatic secretion in dogs.

Authors:  T M Lin; D C Evans; R E Chance; G F Spray
Journal:  Am J Physiol       Date:  1977-03

10.  Translation of melittin messenger RNA in vitro yields a product terminating with glutaminylglycine rather than with glutaminamide.

Authors:  G Suchanek; G Kreil
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205
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  88 in total

1.  Substitution of D-Trp32 in NPY destabilizes the binding transition state to the Y1 receptor site in SK-N-MC cell membranes.

Authors:  R Zand; C L Marcelo; R MacKenzie; L Georgic; D Maclean; W R Dunham
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

Review 2.  NPY and stress 30 years later: the peripheral view.

Authors:  Dalay Hirsch; Zofia Zukowska
Journal:  Cell Mol Neurobiol       Date:  2012-01-24       Impact factor: 5.046

Review 3.  Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones.

Authors:  Amosy E M'Koma; Paul E Wise; Roberta L Muldoon; David A Schwartz; Mary K Washington; Alan J Herline
Journal:  Int J Colorectal Dis       Date:  2007-06-19       Impact factor: 2.571

4.  Vasoconstrictor effects of various neuropeptide Y analogues on the rat tail artery in the presence of phenylephrine.

Authors:  M Tschöpl; R C Miller; J Pelton; J C Stoclet; B Bucher
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

5.  Peptide YY (PYY) immunoreactivity is co-stored with glucagon-related immunoreactants in endocrine cells of the gut and pancreas.

Authors:  A Ali-Rachedi; I M Varndell; T E Adrian; D A Gapp; S Van Noorden; S R Bloom; J M Polak
Journal:  Histochemistry       Date:  1984

6.  Plasma peptide YY (PYY) in dumping syndrome.

Authors:  T E Adrian; R G Long; H S Fuessl; S R Bloom
Journal:  Dig Dis Sci       Date:  1985-12       Impact factor: 3.199

7.  Enterogastrone-like effect of peptide YY is vagally mediated in the dog.

Authors:  T N Pappas; H T Debas; I L Taylor
Journal:  J Clin Invest       Date:  1986-01       Impact factor: 14.808

8.  Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility.

Authors:  J M Lundberg; K Tatemoto; L Terenius; P M Hellström; V Mutt; T Hökfelt; B Hamberger
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

9.  Neuropeptide Y: complete amino acid sequence of the brain peptide.

Authors:  K Tatemoto
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

10.  Neuropeptide tyrosine (NPY): a newly discovered peptide is present in the mammalian respiratory tract.

Authors:  M N Sheppard; J M Polak; J M Allen; S R Bloom
Journal:  Thorax       Date:  1984-05       Impact factor: 9.139
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