Literature DB >> 265590

Translation of melittin messenger RNA in vitro yields a product terminating with glutaminylglycine rather than with glutaminamide.

G Suchanek, G Kreil.   

Abstract

Melittin messenger RNA from queen bee venom glands has been translated in a cell-free system from wheat germ. A product larger than promelittin is formed which has the carboxy-terminal sequence-Gln-Gln-GlyCOOH. Melittin and promelittin from venom glands terminate in -Gln-GlnCONH2. The possible role of the extra glycine residue in the formation of a COOH-terminal amide via a transamidase-like reaction is discussed.

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Year:  1977        PMID： 265590      PMCID： PMC430552          DOI： 10.1073/pnas.74.3.975

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Amino-acid sequence of the alpha-melanocyte-stimulating hormone.

Authors:  J I HARRIS; A B LERNER
Journal:  Nature       Date:  1957-06-29       Impact factor: 49.962

2.  The translation of a human placental lactogen mRNA fraction in heterologous cell-free systems: the synthesis of a possible precursor.

Authors:  I Boime; S Boguslawski; J Caine
Journal:  Biochem Biophys Res Commun       Date:  1975-01-06       Impact factor: 3.575

3.  Homology in amino-terminal sequence of precursors to pancreatic secretory proteins.

Authors:  A Devillers-Thiery; T Kindt; G Scheele; G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

4.  Characterization of promelittin messenger RNA from the venom gland of young queen bees.

Authors:  I Kindås-Mügge; L Frasel; H Diggelmann
Journal:  J Mol Biol       Date:  1976-07-25       Impact factor: 5.469

Review 5.  Proteolytic processing in the biosynthesis of insulin and other proteins.

Authors:  D F Steiner; W Kemmler; H S Tager; J D Peterson
Journal:  Fed Proc       Date:  1974-10

6.  A possible precursor of immunoglobulin light chains.

Authors:  C Milstein; G G Brownlee; T M Harrison; M B Mathews
Journal:  Nat New Biol       Date:  1972-09-27

7.  [Amino acid sequence of MCD-peptide, a specific mast cell-degranulating peptide from bee venom].

Authors:  P Haux
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1969-05

8.  [Sequence analysis of bee venom neurotoxin (apamine) from its tryptic and chymotryptic cleavage products].

Authors:  P Haux; H Sawerthal; E Habermann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1967-06

9.  Biosynthesis of melittin, a toxic peptide from bee venom. Detection of a possible precursor.

Authors:  G Kreil; H Bachmayer
Journal:  Eur J Biochem       Date:  1971-06-11

10.  Staphylococcal protease: a proteolytic enzyme specific for glutamoyl bonds.

Authors:  J Houmard; G R Drapeau
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205
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  18 in total

1.  Amino acid sequence of honeybee prepromelittin synthesized in vitro.

Authors:  G Suchanek; G Kreil; M A Hermodson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

2.  Immunocytochemical evidence for differential distribution of gastrin forms using region-specific monoclonal antibodies.

Authors:  T Azuma; D Abrahm; J H Walsh
Journal:  Gastroenterol Jpn       Date:  1986-08

3.  Detection and partial sequence analysis of gastrin mRNA by using an oligodeoxynucleotide probe.

Authors:  B E Noyes; M Mevarech; R Stein; K L Agarwal
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

4.  Cleavage of honeybee prepromelittin by an endoprotease from rat liver microsomes: identification of intact signal peptide.

Authors:  C Mollay; U Vilas; G Kreil
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

5.  Characterization of structure, dynamics, and detergent interactions of the anti-HIV chemokine variant 5P12-RANTES.

Authors:  Maciej Wiktor; Oliver Hartley; Stephan Grzesiek
Journal:  Biophys J       Date:  2013-12-03       Impact factor: 4.033

6.  Glycine-directed peptide amidation: presence in rat brain of two enzymes that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 (thyrotropin-releasing hormone).

Authors:  J S Kizer; W H Busby; C Cottle; W W Youngblood
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

7.  Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.

Authors:  K Tatemoto
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

8.  Comparison of bovine and mouse pituitary glycoprotein hormone pre-alpha subunits synthesized in vitro.

Authors:  L C Giudice; M J Waxdal; B D Weintraub
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

9.  Extraction and immunochemical characterization of cholecystokinin-like peptides from pig and rat brain.

Authors:  S W Ryder; J Eng; E Straus; R S Yalow
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

10.  Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.

Authors:  W H Fischer; J Spiess
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205
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