Literature DB >> 6951603

Small doses of ARA-C in the treatment of acute myeloid leukaemia: differentiation of myeloid leukaemia cells?

M Housset, M T Daniel, L Degos.   

Abstract

Three patients with acute myeloid leukaemia were treated with small doses of ARA-C (10 mg/m2/12 h, subcutaneous injections) and complete remission was obtained. The small doses of ARA-C, the progressive evolution, the absence of aplasia before remission, the simultaneous presence of normal islets of promyelocytes and leukaemic myeloblasts, favour a differentiating role for the drug rather than an antimitotic effect.

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Year:  1982        PMID: 6951603     DOI: 10.1111/j.1365-2141.1982.tb07297.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN: 0007-1048            Impact factor:   6.998


  27 in total

1.  Enhancement of arabinocytosine (AraC) toxicity to AML cells by a differentiation agent combination.

Authors:  Xuening Wang; Jonathan S Harrison; George P Studzinski
Journal:  J Steroid Biochem Mol Biol       Date:  2015-08-28       Impact factor: 4.292

2.  Therapeutic Implications of PPARgamma in Human Osteosarcoma.

Authors:  Eric R Wagner; Bai-Cheng He; Liang Chen; Guo-Wei Zuo; Wenli Zhang; Qiong Shi; Qing Luo; Xiaoji Luo; Bo Liu; Jinyong Luo; Farbod Rastegar; Connie J He; Yawen Hu; Barrett Boody; Hue H Luu; Tong-Chuan He; Zhong-Liang Deng; Rex C Haydon
Journal:  PPAR Res       Date:  2010-02-16       Impact factor: 4.964

3.  In vitro evidence for dose-dependent cytotoxicity as the predominant effect of low dose Ara-C on human leukemic and normal marrow cells.

Authors:  C S Chan; G P Schechter
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

Review 4.  Novel drugs for older patients with acute myeloid leukemia.

Authors:  G Montalban-Bravo; G Garcia-Manero
Journal:  Leukemia       Date:  2014-08-21       Impact factor: 11.528

5.  Low dose cytosine arabinoside in the treatment of myeloid leukaemias and myelodysplastic syndromes.

Authors:  M Murray; P Sarsfield; E Lawlor; S R McCann
Journal:  Ir J Med Sci       Date:  1988-07       Impact factor: 1.568

Review 6.  Biological response modifiers and differentiation inducers. Current status in cancer research.

Authors:  P Reizenstein; G Mathé
Journal:  Drugs       Date:  1983-09       Impact factor: 9.546

7.  Clinical trial of low-dose Ara-C in the treatment of acute leukemia and myelodysplasia.

Authors:  U Jehn; R De Bock; C Haanen
Journal:  Blut       Date:  1984-05

8.  Low-dose cytosine-arabinoside in the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).

Authors:  H J Weh; R Zschaber; D K Hossfeld
Journal:  Blut       Date:  1984-04

9.  Low-dose Ara-C in the treatment of acute leukemia. Cytotoxicity or differentiation induction?

Authors:  D Hoelzer; A Ganser; B Anger; E Seifried; H Heimpel
Journal:  Blut       Date:  1984-04

10.  In vitro exposure of leukemic cells to low concentration Arabinosyl Cytosine: no evidence of differentiation inducing activity.

Authors:  M R Motta; M Baccarani; S Rizzi; R Fanin; G Fasola; C Poluzzi; S Tura
Journal:  Blut       Date:  1987-05
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