Literature DB >> 6945922

Cytosine arabinoside triphosphate production in human leukaemic myeloblasts: interactions with deoxycytidine.

A L Harris, D G Grahame-Smith.   

Abstract

The effect of 1 mu M deoxycytidine (dC) on Ara-C conversion to Ara-CTP and on inhibition of DNA synthesis by Ara-C was measured in intact leukaemic myeloblasts. dC decreased Ara-CTP production in blasts with high Ara-C phosphorylation, but not those with low activity. The Ki for dC was similar to values found with partially purified deoxycytidine kinase. The change in Ara-CTP concentration was associated with a proportional reduction in inhibition of DNA synthesis. dC decreased the effects of Ara-C by inhibition of Ara-CTP production, rather than by production of dCTP and competition with Ara-CTP. Since low Ara-CTP production in patients' blasts is a predictor of poor therapeutic response to Ara-C, the use of dC with Ara-C may improve the therapeutic index in this group of patients.

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Year:  1981        PMID： 6945922     DOI： 10.1007/bf00258478

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  28 in total

1.  Pyrimidine nucleoside monophosphate kinase from human leukemic blast cells.

Authors:  K R Hande; B A Chabner
Journal:  Cancer Res       Date:  1978-03       Impact factor: 12.701

2.  Deoxycytidine kinase. I. Distribution in normal and neoplastic tissues and interrelationships of deoxycytidine and 1-beta-D-arabinofuranosylcytosine phosphorylation.

Authors:  J P Durham; D H Ives
Journal:  Mol Pharmacol       Date:  1969-07       Impact factor: 4.436

3.  Purification and properties of cytidine deaminase from normal and leukemic granulocytes.

Authors:  B A Chabner; D G Johns; C N Coleman; J C Drake; W H Evans
Journal:  J Clin Invest       Date:  1974-03       Impact factor: 14.808

4.  Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme.

Authors:  J P Durham; D H Ives
Journal:  J Biol Chem       Date:  1970-05-10       Impact factor: 5.157

5.  Uptake and phosphorylation of cytosine arabinoside by normal and leukemic human blood cells in vitro.

Authors:  D Kessel; T C Hall; D Rosenthal
Journal:  Cancer Res       Date:  1969-02       Impact factor: 12.701

6.  Erythrocytic nucleoside diphosphokinase. II. Isolation and kinetics.

Authors:  N Mourad; R E Parks
Journal:  J Biol Chem       Date:  1966-01-25       Impact factor: 5.157

7.  Ion-exchange thin-layer chromatography. XV. Preparation, properties and applications of paper-like PEI-cellulose sheets.

Authors:  K Randerath; E Randerath
Journal:  J Chromatogr       Date:  1966-04

8.  An evaluation of an assay for DNA synthesis in lymphocytes with [3H]thymidine and harvesting on to glass fibre filter discs.

Authors:  T Ahern; G A Taylor; C J Sanderson
Journal:  J Immunol Methods       Date:  1976       Impact factor: 2.303

9.  Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes.

Authors:  C N Coleman; R G Stoller; J C Drake; B A Chabner
Journal:  Blood       Date:  1975-11       Impact factor: 22.113

10.  Pharmacokinetics of cytosine arabinoside in patients with acute myeloid leukaemia.

Authors:  A L Harris; C Potter; C Bunch; J Boutagy; D J Harvey; D G Grahame-Smith
Journal:  Br J Clin Pharmacol       Date:  1979-09       Impact factor: 4.335
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  2 in total

1.  Modulation of the effect of 1-beta-D-arabinofuranosylcytosine based on changes of cytidine deaminase activity in HL60 cells.

Authors:  J N Mejer; B T Mortensen; I J Christensen
Journal:  Med Oncol Tumor Pharmacother       Date:  1990

2.  Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis.

Authors:  K Bhalla; S Grant
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333
  2 in total

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