| Literature DB >> 355893 |
C Coulondre, J H Miller, P J Farabaugh, W Gilbert.
Abstract
In the lacI gene of Escherichia coli spontaneous base substituion hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.Entities:
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Year: 1978 PMID： 355893 DOI： 10.1038/274775a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962