Literature DB >> 6942897

T-cell growth factor (interleukin 2) and terminal transferase activity in human leukemias and lymphoblastic cell lines.

R Mertelsmann, S Gillis, G Steinmann, P Ralph, M Stiehm, B Koziner, M A Moore.   

Abstract

Mononuclear blood cells from patients with different types of leukemia, and from controls as well as cells from established lymphoblastic cell lines were analyzed with respect to terminal transferase (TdT) activity and T-cell growth factor (TCGF; Interleukin 2, IL-2), to determine the significance of TCGF production and response as functional markers for human leukemias. The data obtained so far suggest that the aberrant proliferation and lack of maturation observed in these leukemias may be associated with or be the result of a break-down in cellular-mediated control of proliferation.

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Year:  1981        PMID： 6942897     DOI： 10.1007/bf00320468

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  9 in total

1.  Glucocorticoid-induced inhibition of T cell growth factor production. II. The effect on the in vitro generation of cytolytic T cells.

Authors:  S Gillis; G R Crabtree; K A Smith
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

2.  Functional and morphologic characterization of human T cells continuously grown in vitro.

Authors:  F W Ruscetti; D A Morgan; R C Gallo
Journal:  J Immunol       Date:  1977-07       Impact factor: 5.422

3.  Antigenic and enzymatic phenotypes of the pre-B subclass of acute lymphoblastic leukaemia.

Authors:  M Greaves; W Verbi; L Vogler; M Cooper; R Ellis; K Ganeshaguru; V Hoffbrand; G Janossy; F J Bollum
Journal:  Leuk Res       Date:  1979       Impact factor: 3.156

4.  T-cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice.

Authors:  H Wagner; C Hardt; K Heeg; M Röllinghoff; K Pfizenmaier
Journal:  Nature       Date:  1980-03-20       Impact factor: 49.962

5.  Terminal deoxynucleotidyl transferase as a hematopoietic cell marker.

Authors:  F J Bollum
Journal:  Blood       Date:  1979-12       Impact factor: 22.113

6.  A micromethod for determination of terminal deoxynucleotidyl transferase (TdT) in the diagnostic evaluation of acute leukemias.

Authors:  M J Modak; R Mertelsmann; B Koziner; R Pahwa; M A Moore; B D Clarkson; R A Good
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

7.  Monoclonal cytolytic T-cell lines.

Authors:  P E Baker; S Gillis; K A Smith
Journal:  J Exp Med       Date:  1979-01-01       Impact factor: 14.307

8.  The in vitro generation and sustained culture of nude mouse cytolytic T-lymphocytes.

Authors:  S Gillis; N A Union; P E Baker; K A Smith
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307

9.  Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.

Authors:  J Watson; S Gillis; J Marbrook; D Mochizuki; K A Smith
Journal:  J Exp Med       Date:  1979-10-01       Impact factor: 14.307
  9 in total
  3 in total

1.  Defective T-cell response to PHA and mitogenic monoclonal antibodies in male homosexuals with acquired immunodeficiency syndrome and its in vitro correction by interleukin 2.

Authors:  N Ciobanu; K Welte; G Kruger; S Venuta; J Gold; S P Feldman; C Y Wang; B Koziner; M A Moore; B Safai
Journal:  J Clin Immunol       Date:  1983-10       Impact factor: 8.317

2.  T-cell growth factor production by adult, but not childhood. Acute lymphoblastic leukaemic cells.

Authors:  R Seshadri; C Matthews; H Moore; H Zola
Journal:  Blut       Date:  1984-12

3.  Targeting CD6 for the treatment of experimental autoimmune uveitis.

Authors:  Lingjun Zhang; Yan Li; Wen Qiu; Brent A Bell; Nina Dvorina; William M Baldwin; Nora Singer; Timothy Kern; Rachel R Caspi; David A Fox; Feng Lin
Journal:  J Autoimmun       Date:  2018-02-19       Impact factor: 7.094
  3 in total

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