Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 N-formimidoyl thienamycin (MK0787): in vitro study.

Literature DB >> 6941741

N-formimidoyl thienamycin (MK0787): in vitro study.

Abstract

N-Formimidoyl thienamycin (MK0787) was compared in vitro with three other beta-lactam and two aminoglycoside antibiotics. It was second in activity only to cefotaxime against members of the Enterobacteriaceae and to amikacin against Pseudomonas species. It was the most active antibiotic against Staphylococcus aureus. Resistance (minimal inhibitory concentration, greater than 128 microgram/ml) to N-formimidoyl thienamycin was not observed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1981 PMID： 6941741 PMCID： PMC181385 DOI： 10.1128/AAC.19.1.201

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

1. Thienamycin: new beta-lactam antibiotic with potent broad-spectrum activity.

Authors: S S Weaver; G P Bodey; B M LeBlanc
Journal: Antimicrob Agents Chemother Date: 1979-04 Impact factor: 5.191

2. In vitro activity of thienamycin.

Authors: F P Tally; N V Jacobus; S L Gorbach
Journal: Antimicrob Agents Chemother Date: 1978-09 Impact factor: 5.191

3. Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.

Authors: J S Kahan; F M Kahan; R Goegelman; S A Currie; M Jackson; E O Stapley; T W Miller; A K Miller; D Hendlin; S Mochales; S Hernandez; H B Woodruff; J Birnbaum
Journal: J Antibiot (Tokyo) Date: 1979-01 Impact factor: 2.649

4. MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.

Authors: H Kropp; J G Sundelof; J S Kahan; F M Kahan; J Birnbaum
Journal: Antimicrob Agents Chemother Date: 1980-06 Impact factor: 5.191

5. Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics.

Authors: T Kesado; T Hashizume; Y Asahi
Journal: Antimicrob Agents Chemother Date: 1980-06 Impact factor: 5.191

5 in total

9 in total

1. In vitro activity of N-formimidoyl-thienamycin in comparison to that of moxalactam and cefotaxime against gentamicin-resistant gram-negative bacteria.

Authors: Z Pusztai-Markos; F Pranada
Journal: Eur J Clin Microbiol Date: 1982-02 Impact factor: 3.267

2. The in vitro activity of N-formimidoyl thienamycin compared with other broad-spectrum cephalosporins and with clindamycin and metronidazole.

Authors: G Tischhauser; F H Kayser
Journal: Infection Date: 1983 Jul-Aug Impact factor: 3.553

3. Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis.

Authors: P Patamasucon; G H McCracken
Journal: Antimicrob Agents Chemother Date: 1982-03 Impact factor: 5.191

9. Comparative in vitro activities of N-formimidoyl thienamycin and moxalactam against nonfermentative aerobic gram-negative rods.

Authors: E D O'Donnell; E H Freimer; G L Gilardi; R Raeder
Journal: Antimicrob Agents Chemother Date: 1982-04 Impact factor: 5.191

9 in total

N-formimidoyl thienamycin (MK0787): in vitro study.

1. Thienamycin: new beta-lactam antibiotic with potent broad-spectrum activity.

2. In vitro activity of thienamycin.

3. Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.

4. MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.

5. Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics.

1. In vitro activity of N-formimidoyl-thienamycin in comparison to that of moxalactam and cefotaxime against gentamicin-resistant gram-negative bacteria.

2. The in vitro activity of N-formimidoyl thienamycin compared with other broad-spectrum cephalosporins and with clindamycin and metronidazole.

3. Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis.

Review 4. In vitro activity of imipenem--a review.

5. Susceptibilities of anaerobic bacteria to N-formimidoyl thienamycin (MK0787) and to other antibiotics.

6. Comparative activities of 13 beta-lactam antibiotics.

7. Superior activity of N-formimidoyl thienamycin against gentamicin-resistant Pseudomonas aeruginosa.

8. [N-formimidoyl-thienamycin: in vitro activity in bacteria with resistance to beta-lactam antibiotics or gentamicin].

9. Comparative in vitro activities of N-formimidoyl thienamycin and moxalactam against nonfermentative aerobic gram-negative rods.