Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs.

Literature DB >> 6941695

Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs.

Abstract

A two-locus disease model is presented in which a marker locus interacts epistatically with another unlinked trait to cause the disease. Such a model can lead to disease-marker associations and distortions in the sharing of marker types among affected family members. These effects are quantified. In the case of HLA-disease associations, this model is presented as an alternative to the "hitchhiking" theory of tight linkage leading to linkage disequilibrium.

Mesh：

Substances：

Year: 1981 PMID： 6941695 PMCID： PMC1685026

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

36 in total

1. Genetics of juvenile diabetes mellitus. A recessive gene closely linked to HLA D and with 50 per cent penetrance.

Authors: P Rubinstein; N Suciu-Foca; J F Nicholson
Journal: N Engl J Med Date: 1977-11-10 Impact factor: 91.245

2. Disease susceptibility genes--their identification by multiple case family studies.

Authors: N E Day; M J Simons
Journal: Tissue Antigens Date: 1976-08

3. HLA haplotypes in families with high frequency of multiple sclerosis.

Authors: J E Olsson; E Möller; H Link
Journal: Arch Neurol Date: 1976-12

4. Histocompatibility (HL-A) factors in familial multiple sclerosis. Is multiple sclerosis susceptibility inherited via the HL-A chromosome?

Authors: D A Drachman; W C Davison; K K Mittal
Journal: Arch Neurol Date: 1976-06

5. HL-A, immune-response genes, and disease.

Authors: H O McDevitt; W F Bodmer
Journal: Lancet Date: 1974-06-22 Impact factor: 79.321

Review 6. HL-A antigens and disease. Statistical and genetical considerations.

Authors: A Svejgaard; C Jersild; L S Nielsen; W F Bodmer
Journal: Tissue Antigens Date: 1974

7. Relatives of probands: models for preliminary genetic analysis.

Authors: M A Campbell; R C Elston
Journal: Ann Hum Genet Date: 1971-10 Impact factor: 1.670

8. A note of relative risks.

Authors: M Curie-Cohen
Journal: Tissue Antigens Date: 1977-01

9. The investigation of linkage between a quantitative trait and a marker locus.

Authors: J K Haseman; R C Elston
Journal: Behav Genet Date: 1972-03 Impact factor: 2.805

10. Genetic association of multiple sclerosis and HL-A determinants.

Authors: M Alter; M Harshe; V E Anderson; L Emme; E J Yunis
Journal: Neurology Date: 1976-01 Impact factor: 9.910

23 in total

1. Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data.

Authors: Veronica J Vieland; Jian Huang
Journal: Am J Hum Genet Date: 2003-06-26 Impact factor: 11.025

2. Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions.

Authors: Nilanjan Chatterjee; Zeynep Kalaylioglu; Roxana Moslehi; Ulrike Peters; Sholom Wacholder
Journal: Am J Hum Genet Date: 2006-10-20 Impact factor: 11.025

3. Backward genotype-trait association (BGTA)-based dissection of complex traits in case-control designs.

Authors: Tian Zheng; Hui Wang; Shaw-Hwa Lo
Journal: Hum Hered Date: 2006-11-15 Impact factor: 0.444

4. The power of identity-by-state methods for linkage analysis.

Authors: D T Bishop; J A Williamson
Journal: Am J Hum Genet Date: 1990-02 Impact factor: 11.025

5. Linkage strategies for genetically complex traits. I. Multilocus models.

Authors: N Risch
Journal: Am J Hum Genet Date: 1990-02 Impact factor: 11.025

6. A general statistical model for detecting complex-trait loci by using affected relative pairs in a genome search.

Authors: S L Smalley; J A Woodward; C G Palmer
Journal: Am J Hum Genet Date: 1996-04 Impact factor: 11.025

7. Causal models for investigating complex genetic disease: II. what causal models can tell us about penetrance for additive, heterogeneity, and multiplicative two-locus models.

Authors: Ann M Madsen; Ruth Ottman; Susan E Hodge
Journal: Hum Hered Date: 2011-09-09 Impact factor: 0.444

8. Causal models for investigating complex disease: I. A primer.

Authors: Ann M Madsen; Susan E Hodge; Ruth Ottman
Journal: Hum Hered Date: 2011-09-09 Impact factor: 0.444

9. Optimal strategies for mapping complex diseases in the presence of multiple loci.

Authors: D E Goldgar; D F Easton
Journal: Am J Hum Genet Date: 1997-05 Impact factor: 11.025

10. Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations.

Authors: S E Hodge
Journal: Am J Hum Genet Date: 1993-08 Impact factor: 11.025