| Literature DB >> 693555 |
W P Paré, G B Glavin, G P Vincent.
Abstract
Cimetidine at 25, 50, and 100 mg/kg significantly inhibited gastric acid secretion in rats with chronic gastric cannulas. Rats receiving either 50 or 100 mg/kg of cimetidine secreted significantly less gastric acid 3 hr after injection. Cimetidine failed to reduce the number or size of gastric lesions in rats exposed to the activity-stress procedure, but cimetidine at 100 mg/kg significantly reduced the number and size of gastric lesions in rats subjected to a supine restraint procedure.Entities:
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Year: 1978 PMID： 693555 DOI： 10.1016/0091-3057(78)90270-8
Source DB: PubMed Journal: Pharmacol Biochem Behav ISSN： 0091-3057 Impact factor: 3.533