Literature DB >> 6123239

Different effects of cimetidine and ranitidine on gastric emptying in rats and man.

C Scarpignato, G Bertaccini.   

Abstract

Cimetidine and ranitidine were tested for their effect on gastric emptying in the rat. At low doses, cimetidine was inactive, whereas it significantly delayed emptying rate when administered at higher doses. Ranitidine always accelerated gastric emptying. At variance with rats, ranitidine delayed human gastric emptying whereas cimetidine was completely inactive. All these data are consistent with the idea that these effects of H2-antagonists are independent of H2-receptor blockade.

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Year:  1982        PMID： 6123239     DOI： 10.1007/bf01965135

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

1.  Control of gastric emptying and motility.

Authors:  A R Cooke
Journal:  Gastroenterology       Date:  1975-04       Impact factor: 22.682

2.  Role of cimetidine in gastrointestinal disease: present status and future potential.

Authors:  J J Misiewicz
Journal:  Drugs       Date:  1978-02       Impact factor: 9.546

3.  H2-receptor antagonists protect against aspirin-induced gastric lesions in the rat.

Authors:  K T Bunce; M J Daly; J M Humphray; R Stables
Journal:  Agents Actions       Date:  1981-04

4.  Effect of histamine and related compounds on gastric emptying of the conscious rat.

Authors:  C Scarpignato; G Coruzzi; G Bertaccini
Journal:  Pharmacology       Date:  1981       Impact factor: 2.547

5.  Effects of cimetidine on stress ulcer and gastric acid secretion in the rat.

Authors:  W P Paré; G B Glavin; G P Vincent
Journal:  Pharmacol Biochem Behav       Date:  1978-06       Impact factor: 3.533

6.  Action of caerulein on gastric emptying of the conscious rat.

Authors:  C Scarpignato; T Capovilla; G Bertaccini
Journal:  Arch Int Pharmacodyn Ther       Date:  1980-08

7.  Caerulein delays gastric emptying of solids in man.

Authors:  C Scarpignato; G Zimbaro; F Vitulo; G Bertaccini
Journal:  Arch Int Pharmacodyn Ther       Date:  1981-01
  7 in total
  7 in total

1.  Applied potential tomography. Noninvasive method for measuring gastric emptying of a solid test meal.

Authors:  Y F Mangnall; D D Kerrigan; A G Johnson; N W Read
Journal:  Dig Dis Sci       Date:  1991-12       Impact factor: 3.199

2.  Cholinergic-like effects of the new histamine H2-receptor antagonist ranitidine.

Authors:  G Bertaccini; G Coruzzi
Journal:  Agents Actions       Date:  1982-04

3.  Impact of disease severity on gastric residual volume in critical patients.

Authors:  Chien-Wei Hsu; Shu-Fen Sun; David Lin Lee; Shoa-Lin Lin; Kam-Fai Wong; Hsiu-Hua Huang; Hung-Ju Li
Journal:  World J Gastroenterol       Date:  2011-04-21       Impact factor: 5.742

Review 4.  Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.

Authors:  S M Grant; H D Langtry; R N Brogden
Journal:  Drugs       Date:  1989-06       Impact factor: 9.546

Review 5.  Pharmacokinetic considerations in gastrointestinal motor disorders.

Authors:  G S Hebbard; W M Sun; F Bochner; M Horowitz
Journal:  Clin Pharmacokinet       Date:  1995-01       Impact factor: 6.447

6.  Omeprazole causes delay in gastric emptying of digestible meals.

Authors:  L Benini; G Castellani; E Bardelli; C Sembenini; M T Brentegani; S Caliari; I Vantini
Journal:  Dig Dis Sci       Date:  1996-03       Impact factor: 3.199

7.  Assessment of the variation associated with repeated measurement of gastrointestinal transit times and assessment of the effect of oral ranitidine on gastrointestinal transit times using a wireless motility capsule system in dogs.

Authors:  Jonathan A Lidbury; Jan S Suchodolski; Renata Ivanek; Jörg M Steiner
Journal:  Vet Med Int       Date:  2012-06-26
  7 in total

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