Literature DB >> 6932949

In situ drug delivery.

V A Levin, D C Wright, H D Landahl, C S Patlak, J Csejtey.   

Abstract

Drug delivery to tumours and the accessibility of tumour cells to drugs remains a problem of foremost importance and is affected by many factors. We will discuss models we have developed for drug delivery from tumour capillaries to tumour cells, and drug delivery from well perfused, well oxygenated tumour regions to less well perfused hypoxic regions in terms of computer simulation of drug delivery for the anticancer agent BCNU and the hypoxic cell radiosensitizer misonidazole.

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Year:  1980        PMID： 6932949      PMCID： PMC2149274     

Source DB:  PubMed          Journal:  Br J Cancer Suppl        ISSN： 0306-9443


  4 in total

1.  Factors influencing the survival of rat brain tumor cells after in vitro treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea.

Authors:  K T Wheeler; N Tel; M E Williams; S Sheppard; V A Levin; P M Kabra
Journal:  Cancer Res       Date:  1975-06       Impact factor: 12.701

2.  In vitro evaluation of in vivo brain tumor chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea.

Authors:  M L Rosenblum; K T Wheeler; C B Wilson; M Barker; K D Knebel
Journal:  Cancer Res       Date:  1975-06       Impact factor: 12.701

3.  The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier.

Authors:  V A Levin; H D Landahl; M A Freeman-Dove
Journal:  J Pharmacokinet Biopharm       Date:  1976-12

4.  Relationship of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) pharmacokinetics of uptake, distribution, and tissue/plasma partitioning in rat organs and intracerebral tumors.

Authors:  V A Levin; P A Kabra; M A Freeman-Dove
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333
  4 in total
  6 in total

1.  The effect of dexamethasone on vascular permeability of experimental brain tumours.

Authors:  P J Luthert; J Greenwood; P L Lantos; O E Pratt
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

2.  Pharmacokinetics in experimental and clinical chemotherapy.

Authors:  P Workman
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

3.  Understanding brain penetrance of anticancer drugs.

Authors:  Victor A Levin; Benjamin M Ellingson
Journal:  Neuro Oncol       Date:  2018-04-09       Impact factor: 12.300

4.  Local blood-to-tissue transport in Walker 256 metastatic brain tumors.

Authors:  R G Blasberg; W R Shapiro; P Molnar; C S Patlak; J D Fenstermacher
Journal:  J Neurooncol       Date:  1984       Impact factor: 4.130

5.  Heuristic modeling of drug delivery to malignant brain tumors.

Authors:  V A Levin; C S Patlak; H D Landahl
Journal:  J Pharmacokinet Biopharm       Date:  1980-06

Review 6.  Mitochondrial trifunctional protein defects: clinical implications and therapeutic approaches.

Authors:  R Scott Rector; R Mark Payne; Jamal A Ibdah
Journal:  Adv Drug Deliv Rev       Date:  2008-07-04       Impact factor: 15.470
  6 in total

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