Literature DB >> 29474640

Understanding brain penetrance of anticancer drugs.

Victor A Levin1,2, Benjamin M Ellingson3.   

Abstract

This paper explicates the impact of tumor capillary permeability for glioma World Health Organization (WHO) grades II to IV on brain-penetrant drug entry and distribution within the tumor and the brain adjacent to tumor (leading edge). In addition, we consider the distribution of non-brain penetrant drugs and how, in some cases, large-molecular-weight drugs might achieve good distribution into tumor and brain adjacent to tumor.

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Year:  2018        PMID： 29474640      PMCID： PMC5892153          DOI： 10.1093/neuonc/noy018

Source DB:  PubMed          Journal:  Neuro Oncol        ISSN： 1522-8517            Impact factor:   12.300


  42 in total

1.  Chris Lipinski discusses life and chemistry after the Rule of Five.

Authors:  Christopher A Lipinski
Journal:  Drug Discov Today       Date:  2003-01-01       Impact factor: 7.851

2.  CNS Anticancer Drug Discovery and Development Conference White Paper.

Authors:  Victor A Levin; Peter J Tonge; James M Gallo; Marc R Birtwistle; Arvin C Dar; Antonio Iavarone; Patrick J Paddison; Timothy P Heffron; William F Elmquist; Jean E Lachowicz; Ted W Johnson; Forest M White; Joohee Sul; Quentin R Smith; Wang Shen; Jann N Sarkaria; Ramakrishna Samala; Patrick Y Wen; Donald A Berry; Russell C Petter
Journal:  Neuro Oncol       Date:  2015-11       Impact factor: 12.300

3.  Relationship of octanol/water partition coefficient and molecular weight to cellular permeability and partitioning in s49 lymphoma cells.

Authors:  V A Levin; D Dolginow; H D Landahl; C Yorke; J Csejtey
Journal:  Pharm Res       Date:  1984-11       Impact factor: 4.200

Review 4.  Pharmacological principles of brain tumor chemotherapy.

Authors:  V A Levin
Journal:  Adv Neurol       Date:  1976

5.  Drug delivery to CNS tumors.

Authors:  V A Levin; H D Landahl; C S Patlak
Journal:  Cancer Treat Rep       Date:  1981

6.  Permeability characteristics of brain adjacent to tumors in rats.

Authors:  V A Levin; M Freeman-Dove; H D Landahl
Journal:  Arch Neurol       Date:  1975-12

7.  Relationship of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) pharmacokinetics of uptake, distribution, and tissue/plasma partitioning in rat organs and intracerebral tumors.

Authors:  V A Levin; P A Kabra; M A Freeman-Dove
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

8.  FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme.

Authors:  Martin H Cohen; Yuan Li Shen; Patricia Keegan; Richard Pazdur
Journal:  Oncologist       Date:  2009-11-06

9.  Heuristic modeling of drug delivery to malignant brain tumors.

Authors:  V A Levin; C S Patlak; H D Landahl
Journal:  J Pharmacokinet Biopharm       Date:  1980-06

10.  ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope.

Authors:  Andrew C Phillips; Erwin R Boghaert; Kedar S Vaidya; Michael J Mitten; Suzanne Norvell; Hugh D Falls; Peter J DeVries; Dong Cheng; Jonathan A Meulbroek; Fritz G Buchanan; Laura M McKay; Neal C Goodwin; Edward B Reilly
Journal:  Mol Cancer Ther       Date:  2016-02-04       Impact factor: 6.261
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Review 2.  Therapeutic Response Assessment of High-Grade Gliomas During Early-Phase Drug Development in the Era of Molecular and Immunotherapies.

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Journal:  Cancer J       Date:  2021 Sep-Oct 01       Impact factor: 3.360

3.  Haloperidol Induced Cell Cycle Arrest and Apoptosis in Glioblastoma Cells.

Authors:  Fotios Papadopoulos; Rafaela Isihou; George A Alexiou; Thomas Tsalios; Evrysthenis Vartholomatos; Georgios S Markopoulos; Chrissa Sioka; Pericles Tsekeris; Athanasios P Kyritsis; Vasiliki Galani
Journal:  Biomedicines       Date:  2020-12-11

4.  The First Insight Into the Supramolecular System of D,L-α-Difluoromethylornithine: A New Antiviral Perspective.

Authors:  Joanna Bojarska; Roger New; Paweł Borowiecki; Milan Remko; Martin Breza; Izabela D Madura; Andrzej Fruziński; Anna Pietrzak; Wojciech M Wolf
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