| Literature DB >> 69327 |
G Stetten, S A Latt, R L Davidson.
Abstract
Cells that have incorporated 5-bromodeoxyuridine (BrdU) into their DNA become extremely sensitive to photoinduced killing after treatment with the dye, 33258 Hoechst. Under appropriate conditions the dye increases the efficiency of killing by a factor of approximately 10(4). This enhanced photosensitivity suggests that the combination of BrdU, dye, and light can be used to select conditional lethal mutants.Entities:
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Year: 1976 PMID： 69327 DOI： 10.1007/BF01538967
Source DB: PubMed Journal: Somatic Cell Genet ISSN： 0098-0366