Reactions of guinea pig subcutaneous connective tissue following exposure to sodium hypochlorite.

Experiments aimed at determining which concentration of sodium hypochlorite should be used clinically to achieve optimal dissolving and bactericidal but nonirritating effect are reported. The results of in vivo experiments, with polyethylene tubes implanted in the backs of guinea pigs, show that there is no significant difference in inflammatory response between sodium hypochlorite solutions in the concentration range of 2 to 8 percent, pH 12, and sterile physiologic saline.