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Literature DB >> 6928692

Structural details of membrane-bound acetylcholine receptor from Tropedo marmorata.

H P Zingsheim, D C Neugebauer, F J Barrantes, J Frank.

Abstract

A projection, at 15- to 20-A resolution, is presented of the structure of the membrane-bound acetylcholine receptor protein from Torpedo marmorata. The projection has its axis perpendicular to the membrane plane; its main contribution originates from a hydrated portion of the protein, which extends from the membrane into the aqueous medium. The structure is distinctly asymmetric, with individual morphological subunits barely resolvable. These results have been obtained by noncrystallographic averaging, using correlation functions, applied to electron micrographs of receptor-rich membrane fragments. The micrographs had been taken with minimal beam exposure in a scanning transmission electron microscope.

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Year: 1980 PMID： 6928692 PMCID： PMC348401 DOI： 10.1073/pnas.77.2.952

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

13 in total

1. Signal to noise enhancement in dark field electron micrographs of vasopressin: filtering of arrays of images in reciprocal space.

Authors: F P Ottensmeyer; J W Andrew; D P Bazett-Jones; A S Chan; J Hewitt
Journal: J Microsc Date: 1977-04 Impact factor: 1.758

2. Purification and characterization of the cholinergic receptor protein in its membrane-bound and detergent-soluble forms from the electric organ of Torpedo marmorata.

Authors: A Sobel; J P Changeux
Journal: Biochem Soc Trans Date: 1977 Impact factor: 5.407

3. Electron microscopy of the stacked disk aggregate of tobacco mosaic virus protein. II. The influence of electron irradiation of the stain distribution.

Authors: P N Unwin
Journal: J Mol Biol Date: 1974-08-25 Impact factor: 5.469

4. Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata.

Authors: J Cartaud; E L Benedetti; J B Cohen; J C Meunier; J P Changeux
Journal: FEBS Lett Date: 1973-06-15 Impact factor: 4.124

5. Ultrastructure of isolated membranes of Torpedo electric tissue.

Authors: E Nickel; L T Potter
Journal: Brain Res Date: 1973-07-27 Impact factor: 3.252

6. Molecular forms of acetylcholine receptor. Effects of calcium ions and a sulfhydryl reagent on the occurrence of oligomers.

Authors: H W Chang; E Bock
Journal: Biochemistry Date: 1977-10-04 Impact factor: 3.162

7. Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica.

Authors: M J Ross; M W Klymkowsky; D A Agard; R M Stroud
Journal: J Mol Biol Date: 1977-11 Impact factor: 5.469

8. Harmonic analysis of electron microscope images with rotational symmetry.

Authors: R A Crowther; L A Amos
Journal: J Mol Biol Date: 1971-08-28 Impact factor: 5.469

9. Membranes rich in acetylcholine receptor: characterization and reconstitution to excitable membranes from exogenous lipids.

Authors: W Schiebler; F Hucho
Journal: Eur J Biochem Date: 1978-04

10. A morphological study of the cholinergic receptor protein from Torpedo marmorata in its membrane environment and in its detergent-extracted purified form.

Authors: J Cartaud; E L Benedetti
Journal: J Cell Sci Date: 1978-02 Impact factor: 5.285

11 in total

8. Consequences of alkaline treatment for the ultrastructure of the acetylcholine-receptor-rich membranes from Torpedo marmorata electric organ.

Authors: J Cartaud; A Sobel; A Rousselet; P F Devaux; J P Changeux
Journal: J Cell Biol Date: 1981-08 Impact factor: 10.539

9. Oligomeric forms of the membrane-bound acetylcholine receptor disclosed upon extraction of the Mr 43,000 nonreceptor peptide.

Authors: F J Barrantes
Journal: J Cell Biol Date: 1982-01 Impact factor: 10.539

10. Cytoplasmic surface structure in postsynaptic membranes from electric tissue visualized by tannic-acid-mediated negative contrasting.

Authors: R Sealock
Journal: J Cell Biol Date: 1982-02 Impact factor: 10.539

Structural details of membrane-bound acetylcholine receptor from Tropedo marmorata.

1. Signal to noise enhancement in dark field electron micrographs of vasopressin: filtering of arrays of images in reciprocal space.

2. Purification and characterization of the cholinergic receptor protein in its membrane-bound and detergent-soluble forms from the electric organ of Torpedo marmorata.

3. Electron microscopy of the stacked disk aggregate of tobacco mosaic virus protein. II. The influence of electron irradiation of the stain distribution.

4. Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata.

5. Ultrastructure of isolated membranes of Torpedo electric tissue.

6. Molecular forms of acetylcholine receptor. Effects of calcium ions and a sulfhydryl reagent on the occurrence of oligomers.

7. Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica.

8. Harmonic analysis of electron microscope images with rotational symmetry.

9. Membranes rich in acetylcholine receptor: characterization and reconstitution to excitable membranes from exogenous lipids.

10. A morphological study of the cholinergic receptor protein from Torpedo marmorata in its membrane environment and in its detergent-extracted purified form.

1. Evidence that receptors mediating central synaptic potentials extend beyond the postsynaptic density.

2. Crystalline arrays of membrane-bound acetylcholine receptor.

3. Structural models of the nicotinic acetylcholine receptor and its toxin-binding sites.

Review 4. Single-particle reconstruction of biological macromolecules in electron microscopy--30 years.

Review 5. Structural answers and persistent questions about how nicotinic receptors work.

6. Dimeric arrangement and structure of the membrane-bound acetylcholine receptor studied by electron microscopy.

7. Tubular crystals of acetylcholine receptor.

8. Consequences of alkaline treatment for the ultrastructure of the acetylcholine-receptor-rich membranes from Torpedo marmorata electric organ.

9. Oligomeric forms of the membrane-bound acetylcholine receptor disclosed upon extraction of the Mr 43,000 nonreceptor peptide.

10. Cytoplasmic surface structure in postsynaptic membranes from electric tissue visualized by tannic-acid-mediated negative contrasting.