Literature DB >> 6927936

Rotational therapy with a colchicine analog in chronic granulocytic leukemia.

D C Stolinsky, J M Weiner, J R Bateman.   

Abstract

9 patients with chronic granulocytic leukemia were treated sequentially with busulfan, 6-mercaptopurine, and trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36354). Smoothness of control of the disease was similar with busulfan and 6-mercaptopurine, but it was significantly poorer with TMCA. Toxic effects of therapy and median survival were similar to those observed with conventional therapy.

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Year:  1980        PMID: 6927936     DOI: 10.1159/000225404

Source DB:  PubMed          Journal:  Oncology        ISSN: 0030-2414            Impact factor:   2.935


  1 in total

1.  Phase I toxicity and pharmacology study of trimethylcolchicinic acid in patients with advanced malignancies.

Authors:  E Hu; R Ko; R Koda; P Rosen; S Jeffers; M Scholtz; F Muggia
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

  1 in total

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