| Literature DB >> 2208579 |
E Hu1, R Ko, R Koda, P Rosen, S Jeffers, M Scholtz, F Muggia.
Abstract
A phase I study of trimethylcolchicinic acid (TMCA) given orally once daily for 5 days every 3rd week was performed in 19 patients with advanced malignancies. Myelosuppression and mucositis were the major toxicities observed. Serum TMCA levels were monitored and appear to be useful in predicting toxicities. A partial response was seen in one lymphoma patient and stabilization of disease was noted in one patient each with prostatic and ovarian cancer.Entities:
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Year: 1990 PMID： 2208579 DOI： 10.1007/bf02897294
Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333