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Literature DB >> 69273

Clonidine-induced locomotor hyperactivity in rats. The role of central postsynaptic alpha-adrenoceptors.

I Zebrowska-Lupina, E Przegalinski, M Sloniec, Z Kleinrok.

Abstract

The alpha-adrenergic agonist, clonidine, causes sedation in normal rats. The present study demonstrates that clonidine evokes strong locomotor stimulation in rats pretreated with 6-hydroxydopamine plus reserpine. Similar, but less intensive hyperactivity is observed in rats given clonidine after combined pretreatment with 6-hydroxydopamine plus p-chlorophenylalanine plus alpha-methyl-p-tyrosine, or with reserpine plus low doses of yohimbine. The aplha-adrenolytic drugs, phenoxybenzamine, phentolamine and aceperone, as well as high doses of yohimbine, antagonise the clonidine-induced locomotor stimulation; in contrast, the dopamine receptor blocking agents, pimozide and spiroperiodol, exert no antagonistic effect. The results indicate that in the brain of normal animals, clonidine predominantly activates presynaptic alpha-adrenoceptors on noradrenergic neurones and thereby induces sedation. After destruction of the noradrenergic fibres by 6-hydroxydopamine plus reserpine, activation of postsynaptic alpha-adrenoceptors prevails so that hyperactivity results.

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Year: 1977 PMID： 69273 DOI： 10.1007/BF00509265

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

34 in total

1. Potentiation of amphetamine-induced hyperactivity by acute but not by chronic para-chlorophenylalanine treatment in the rat.

Authors: E Cannon; R J Wyatt; J C Gillin
Journal: Life Sci Date: 1976-04-01 Impact factor: 5.037

2. The demonstration of a change in adrenergic receptor sensitivity in the central nervous system of mice after withdrawal from long-term treatment with haloperidol.

Authors: R Dunstan; D M Jackson
Journal: Psychopharmacology (Berl) Date: 1976-07-09 Impact factor: 4.530

3. Involvement of alpha-receptors in clonidine-induced inhibition of transmitter release from central monoamine neurones.

Authors: K Starke; H Montel
Journal: Neuropharmacology Date: 1973-11 Impact factor: 5.250

4. Sedative effects of alpha-sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs.

Authors: B Delbarre; H Schmitt
Journal: Eur J Pharmacol Date: 1971 Impact factor: 4.432

5. Serotonergic inhibition of catecholamine-induced behavioral arousal.

Authors: P D Mabry; B A Campbell
Journal: Brain Res Date: 1973-01-30 Impact factor: 3.252

6. Dopamine and noradrenaline receptor stimulation: reversal of reserpine-induced suppression of motor activity.

Authors: N E Andén; U Strömbom; T H Svensson
Journal: Psychopharmacologia Date: 1973

7. On the mode of action of apomorphine.

Authors: B Costall; R J Naylor
Journal: Eur J Pharmacol Date: 1973-03 Impact factor: 4.432

8. A further attempt to characterize sedative receptors activated by clonidine in chickens and mice.

Authors: B Delbarre; H Schmitt
Journal: Eur J Pharmacol Date: 1973-06 Impact factor: 4.432

9. Evidence for a central alpha-sympathomimetic action of clonidine in the rat.

Authors: L Finch; R E Buckingham; R A Moore; T J Bucher
Journal: J Pharm Pharmacol Date: 1975-03 Impact factor: 3.765

10. Catecholamine receptor agonists: effects on motor activity and rate of tyrosine hydroxylation in mouse brain.

Authors: U Strömbom
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1976 Impact factor: 3.000

24 in total

1. Involvement of presynaptic alpha-adrenoceptors in the cardiovascular and sedative effects of FLA-136.

Authors: P B Timmermans; E Lam; P A van Zwieten
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1979-03 Impact factor: 3.000

2. Depression of exploratory activity by clonidine in rats as a model for the detection of relative pre- and postsynaptic central noradrenergic receptor selectivity of alpha-adrenolytic drugs.

Authors: A Delini-Stula; P Baumann; O Büch
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1979-06 Impact factor: 3.000

10. Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.

Authors: C K Atterwill; S J Bunn; D J Atkinson; S L Smith; D J Heal
Journal: J Neural Transm Date: 1984 Impact factor: 3.575

Clonidine-induced locomotor hyperactivity in rats. The role of central postsynaptic alpha-adrenoceptors.

1. Potentiation of amphetamine-induced hyperactivity by acute but not by chronic para-chlorophenylalanine treatment in the rat.

2. The demonstration of a change in adrenergic receptor sensitivity in the central nervous system of mice after withdrawal from long-term treatment with haloperidol.

3. Involvement of alpha-receptors in clonidine-induced inhibition of transmitter release from central monoamine neurones.

4. Sedative effects of alpha-sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs.

5. Serotonergic inhibition of catecholamine-induced behavioral arousal.

6. Dopamine and noradrenaline receptor stimulation: reversal of reserpine-induced suppression of motor activity.

7. On the mode of action of apomorphine.

8. A further attempt to characterize sedative receptors activated by clonidine in chickens and mice.

9. Evidence for a central alpha-sympathomimetic action of clonidine in the rat.

10. Catecholamine receptor agonists: effects on motor activity and rate of tyrosine hydroxylation in mouse brain.

1. Involvement of presynaptic alpha-adrenoceptors in the cardiovascular and sedative effects of FLA-136.

2. Depression of exploratory activity by clonidine in rats as a model for the detection of relative pre- and postsynaptic central noradrenergic receptor selectivity of alpha-adrenolytic drugs.

3. Naloxone-precipitated withdrawal reveals sensitization to neurotransmitters in morphine tolerant/dependent rats.

4. A study of the possible influence of central 5-HT function on clonidine-induced hypoactivity responses in mice.

5. Modulation of motor activity by alpha 1- and alpha 2-adrenoceptor stimulation in mice.

6. Effects of alpha 2-agonists on morphine withdrawal behaviour: potentiation of jumping mediated by alpha 2-receptors.

7. Inhibitory alpha 2-adrenergic mechanism regulating gastric secretion in pylorus-ligated rats.

8. Clonidine-induced sedation in rats: evidence for mediation by postsynaptic alpha 2-adrenoreceptors.

9. Spinal modulation of acoustic startle: opposite effects of clonidine and d-amphetamine.

10. Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.