Literature DB >> 6127372

Clonidine-induced sedation in rats: evidence for mediation by postsynaptic alpha 2-adrenoreceptors.

C Spyraki, H C Fibiger.   

Abstract

The effect of low doses of clonidine on exploration and motility was investigated in rats after destruction of central noradrenergic systems by 6-hydroxydopamine (6-OHDA) or DSP-4. In accordance with previous results, clonidine decreased exploration and motility in control animals. This sedative effect of clonidine was potentiated in animals that suffered selective and extensive depletions of brain NA as a result of neonatal treatment with 6-OHDA. Depletion of NA by administration of DSP-4 to adult animals did not influence clonidine's sedative effects. Yohimbine, but not phentolamine, antagonized clonidine-induced hypomotility both in control and in neonatal 6-OHDA treated groups. The results suggest that clonidine-induced sedation is mediated by postsynaptic alpha 2-adrenoreceptors.

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Year:  1982        PMID： 6127372     DOI： 10.1007/bf01254925

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  29 in total

1.  Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane.

Authors:  J M Cedarbaum; G K Aghajanian
Journal:  Brain Res       Date:  1976-08-13       Impact factor: 3.252

Review 2.  Regulation of noradrenaline release by presynaptic receptor systems.

Authors:  K Starke
Journal:  Rev Physiol Biochem Pharmacol       Date:  1977       Impact factor: 5.545

3.  Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine.

Authors:  T H Svensson; B S Bunney; G K Aghajanian
Journal:  Brain Res       Date:  1975-07-11       Impact factor: 3.252

Review 4.  Local regulation of adrenergic neurotransmission.

Authors:  T C Westfall
Journal:  Physiol Rev       Date:  1977-10       Impact factor: 37.312

5.  Depression of exploratory activity by clonidine in rats as a model for the detection of relative pre- and postsynaptic central noradrenergic receptor selectivity of alpha-adrenolytic drugs.

Authors:  A Delini-Stula; P Baumann; O Büch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-06       Impact factor: 3.000

6.  Catecholamine receptors on locus coeruleus neurons: pharmacological characterization.

Authors:  J M Cedarbaum; G K Aghajanian
Journal:  Eur J Pharmacol       Date:  1977-08-15       Impact factor: 4.432

7.  Evidence for a central noradrenaline receptor stimulation by clonidine.

Authors:  N E Andén; H Corrodi; K Fuxe; B Hökfelt; T Hökfelt; C Rydin; T Svensson
Journal:  Life Sci       Date:  1970-05-01       Impact factor: 5.037

8.  Long-lasting peripheral and central effects of 6-hydroxydopamine in rats.

Authors:  D W Clark; R Laverty; E L Phelan
Journal:  Br J Pharmacol       Date:  1972-02       Impact factor: 8.739

9.  Behavioural and biochemical effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155) on the central nervous system.

Authors:  R Laverty; K M Taylor
Journal:  Br J Pharmacol       Date:  1969-02       Impact factor: 8.739

10.  Clonidine-induced locomotor hyperactivity in rats. The role of central postsynaptic alpha-adrenoceptors.

Authors:  I Zebrowska-Lupina; E Przegalinski; M Sloniec; Z Kleinrok
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-04       Impact factor: 3.000
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  16 in total

1.  Effect of clonidine on ultrasonic vocalization in preweaning rats.

Authors:  E Hård; J Engel; A S Lindh
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

Review 2.  The role of the central noradrenergic system in behavioral inhibition.

Authors:  Eric A Stone; Yan Lin; Yasmeen Sarfraz; David Quartermain
Journal:  Brain Res Rev       Date:  2011-03-05

3.  Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility.

Authors:  Nobuhito Kikuchi; Masahiro Irifune; Yoshitaka Shimizu; Keita Yoshida; Katsuya Morita; Takashi Kanematsu; Norimitsu Morioka; Yoshihiro Nakata; Norio Sakai
Journal:  Psychopharmacology (Berl)       Date:  2014-05-31       Impact factor: 4.530

4.  A study of the possible influence of central 5-HT function on clonidine-induced hypoactivity responses in mice.

Authors:  D J Heal; J Philpot
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 5.  Are the pharmacology and physiology of α₂ adrenoceptors determined by α₂-heteroreceptors and autoreceptors respectively?

Authors:  Ralf Gilsbach; Lutz Hein
Journal:  Br J Pharmacol       Date:  2012-01       Impact factor: 8.739

6.  Noradrenergic modulation of risk/reward decision making.

Authors:  David R Montes; Colin M Stopper; Stan B Floresco
Journal:  Psychopharmacology (Berl)       Date:  2015-03-13       Impact factor: 4.530

7.  Effects of clonidine and alpha-adrenoceptor antagonists on motor activity in DSP4-treated mice I: dose-, time- and parameter-dependency.

Authors:  T Archer; A Fredriksson
Journal:  Neurotox Res       Date:  2000-04       Impact factor: 3.911

8.  Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic alpha 2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochloride.

Authors:  D J Heal; M R Prow; W R Buckett
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

9.  Manipulating Decisiveness in Decision Making: Effects of Clonidine on Hippocampal Search Strategies.

Authors:  Seiichiro Amemiya; A David Redish
Journal:  J Neurosci       Date:  2016-01-20       Impact factor: 6.167

10.  Effects of alpha-adrenoceptor agonists in chronic morphine administered DSP4-treated rats: evidence for functional cross-sensitization.

Authors:  T Archer; A Fredriksson
Journal:  Neurotox Res       Date:  2001-10       Impact factor: 3.911
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