Literature DB >> 69024

In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model.

K E Kinnamon, E A Steck, W L Hanson, W L Chapman.   

Abstract

Nine of 25 carefully selected compounds (from a stock of more than 200 000 chemical species amassed principally as a result of testing against other parasitic diseases) were found to have significant suppressive activity against the parasites in the blood of a Trypanosoma cruzi mouse model. Eight of these compounds evaluated in this model had suppressive activity equal to or greater than the reference compound, nifurtimox. For the first time, suppressive activity against T. cruzi is reported for a 7-aminoquinoline, a phosphonium salt, and TAC pamoate; The biological model is believed to be able to serve as a means of identifying other new "leads* in seeking drugs broadly effective against T=ruzi infections in man.

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Year:  1977        PMID： 69024     DOI： 10.1021/jm00216a001

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Potential use of WR6026 as prophylaxis against transfusion-transmitted American trypanosomiasis.

Authors:  E Chiari; A B Oliveira; M A Prado; R J Alves; L M Galvão; F G Araujo
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

2.  Phosphonium lipocations as antiparasitic agents.

Authors:  Timothy E Long; Xiao Lu; Melina Galizzi; Roberto Docampo; Jiri Gut; Philip J Rosenthal
Journal:  Bioorg Med Chem Lett       Date:  2012-02-23       Impact factor: 2.823

3.  1-(substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi in mice.

Authors:  J C Chabala; V B Waits; T Ikeler; A A Patchett; L Payne; L H Peterson; R A Reamer; K Hoogsteen; M Wyvratt; W L Hanson
Journal:  Experientia       Date:  1991-01-15

4.  Preclinical evaluation of novel triphenylphosphonium salts with broad-spectrum activity.

Authors:  Melissa Millard; Divya Pathania; Yumna Shabaik; Laleh Taheri; Jinxia Deng; Nouri Neamati
Journal:  PLoS One       Date:  2010-10-04       Impact factor: 3.240

5.  Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei.

Authors:  Abdulsalam A M Alkhaldi; Jan Martinek; Brian Panicucci; Christophe Dardonville; Alena Zíková; Harry P de Koning
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2015-12-11       Impact factor: 4.077

6.  Synthesis, Biological Activity and In Silico Pharmacokinetic Prediction of a New 2-Thioxo-Imidazoldidin-4-One of Primaquine.

Authors:  Mariana Pereira; Guy Caljon; Maria João Gouveia; Louis Maes; Nuno Vale
Journal:  Pharmaceuticals (Basel)       Date:  2021-02-27
  6 in total

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