Literature DB >> 22414614

Phosphonium lipocations as antiparasitic agents.

Timothy E Long1, Xiao Lu, Melina Galizzi, Roberto Docampo, Jiri Gut, Philip J Rosenthal.   

Abstract

Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi. Published by Elsevier Ltd.

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Year:  2012        PMID： 22414614      PMCID： PMC3321104          DOI： 10.1016/j.bmcl.2012.02.045

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  41 in total

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Authors:  G F Kelso; C M Porteous; C V Coulter; G Hughes; W K Porteous; E C Ledgerwood; R A Smith; M P Murphy
Journal:  J Biol Chem       Date:  2000-11-22       Impact factor: 5.157

Review 2.  Recent developments in the chemotherapy of Chagas disease.

Authors:  R Docampo
Journal:  Curr Pharm Des       Date:  2001-08       Impact factor: 3.116

Review 3.  Mitochondria and trypanosomatids: targets and drugs.

Authors:  Lianet Monzote Fidalgo; Lars Gille
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Review 4.  Specific chemotherapy of Chagas disease: controversies and advances.

Authors:  Julio A Urbina; Roberto Docampo
Journal:  Trends Parasitol       Date:  2003-11

5.  Nuclear magnetic resonance-visible lipids induced by cationic lipophilic chemotherapeutic agents are accompanied by increased lipid droplet formation and damaged mitochondria.

Authors:  Edward J Delikatny; Wendy A Cooper; Susan Brammah; Nalayini Sathasivam; Darryl C Rideout
Journal:  Cancer Res       Date:  2002-03-01       Impact factor: 12.701

Review 6.  Antimetabolites of coenzyme Q. Their potential application as antimalarials.

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Journal:  Angew Chem Int Ed Engl       Date:  1974-09       Impact factor: 15.336

7.  Synthesis, electrochemical and spectral properties of some omega-N-quinonyl amino acids.

Authors:  S Bittner; S Gorohovsky; Levi O Paz-Tal; J Y Becker
Journal:  Amino Acids       Date:  2002       Impact factor: 3.520

8.  The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum.

Authors:  Richard J W Allen; Kiaran Kirk
Journal:  J Biol Chem       Date:  2003-11-20       Impact factor: 5.157

9.  In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model.

Authors:  K E Kinnamon; E A Steck; W L Hanson; W L Chapman
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10.  Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant.

Authors:  Jordi Asin-Cayuela; Abdul-Rahman B Manas; Andrew M James; Robin A J Smith; Michael P Murphy
Journal:  FEBS Lett       Date:  2004-07-30       Impact factor: 4.124
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Review 2.  Phthalimide analogs for antimalarial drug discovery.

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3.  1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues.

Authors:  Xiao Lu; Ali Altharawi; Jiri Gut; Philip J Rosenthal; Timothy E Long
Journal:  ACS Med Chem Lett       Date:  2012-10-01       Impact factor: 4.345

4.  Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents.

Authors:  Ming Li; Samuel A Nyantakyi; Pooja Gopal; Dinah Binte Aziz; Thomas Dick; Mei-Lin Go
Journal:  ACS Med Chem Lett       Date:  2017-10-09       Impact factor: 4.345

Review 5.  Menadione: a platform and a target to valuable compounds synthesis.

Authors:  Acácio S de Souza; Ruan Carlos B Ribeiro; Dora C S Costa; Fernanda P Pauli; David R Pinho; Matheus G de Moraes; Fernando de C da Silva; Luana da S M Forezi; Vitor F Ferreira
Journal:  Beilstein J Org Chem       Date:  2022-04-11       Impact factor: 2.544

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Journal:  Antimicrob Agents Chemother       Date:  2022-07-20       Impact factor: 5.938
  6 in total

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