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Literature DB >> 6897522

Does pirenzepine distinguish between 'subtypes' of muscarinic receptors?

Abstract

Pharmacological studies with pirenzepine were carried out on the isolated ileum and atrium of the guinea-pig and on the acid secretion from the isolated stomach of the mouse. Pirenzepine inhibited the bethanechol-evoked changes in all three organs in a dose-dependent manner. The slopes of the Schild-plots confirmed the competitive nature of the antagonism by pirenzepine. The estimated pA2-values were very similar. Based on these data, it might be concluded that pirenzepine is an anticholinoceptor compound without specific affinity for gastric muscarinic receptors.

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Year: 1982 PMID： 6897522 PMCID： PMC2044673 DOI： 10.1111/j.1476-5381.1982.tb09332.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

6 in total

1. An isolated mammalian stomach preparation for studying the effect of substances on gastric acid secretion.

Authors: I Szelenyi
Journal: Arzneimittelforschung Date: 1981

2. Effects of H2-receptor antagonists and anticholinoceptor drugs on gastric and salivary secretion induced by bethanechol in the anaesthetized dog.

Authors: M J Daly; J M Humphray; R Stables
Journal: Br J Pharmacol Date: 1982-07 Impact factor: 8.739

3. Analysis of anomalous pKb values for metiamide and atropine in the isolated stomach of the mouse.

Authors: J A Angus; J W Black
Journal: Br J Pharmacol Date: 1979-09 Impact factor: 8.739

4. Some quantitative uses of drug antagonists.

Authors: O ARUNLAKSHANA; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1959-03

5. Pirenzepine distinguishes between different subclasses of muscarinic receptors.

Authors: R Hammer; C P Berrie; N J Birdsall; A S Burgen; E C Hulme
Journal: Nature Date: 1980-01-03 Impact factor: 49.962

6. Cholinergic pathway of gastric acid secretion in the isolated whole stomach of the mouse.

Authors: I Szelenyi; H Vergin
Journal: Pharmacology Date: 1980 Impact factor: 2.547

6 in total

12 in total

1. Telenzepine inhibits electrically-stimulated, acetylcholine plus histamine-mediated acid secretion in the mouse isolated stomach by blockade of M1 muscarine receptors.

Authors: W Kromer; E Baron; R Boer; M Eltze
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1991-01 Impact factor: 3.000

2. Characterization of the muscarine receptor type on paracrine cells activated by McN-A-343 in the mouse isolated stomach.

Authors: W Kromer; E Baron; M Beinborn; R Boer; M Eltze
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1990-03 Impact factor: 3.000

3. Stimulation by McN-A-343 and blockade by telenzepine of acid secretion in the mouse isolated stomach at histamine-liberating cells.

Authors: W Kromer; E Baron; M Beinborn; M Eltze; W A Simon
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1989-07 Impact factor: 3.000

4. Pharmacological analysis of the inhibition by pirenzepine and atropine of vagal-stimulated acid secretion in the isolated stomach of the mouse.

Authors: J W Black; N P Shankley
Journal: Br J Pharmacol Date: 1986-05 Impact factor: 8.739

5. Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach.

Authors: J W Black; N P Shankley
Journal: Br J Pharmacol Date: 1985-11 Impact factor: 8.739

6. Comparative studies of the effects of some antimuscarinic agents on gastric damage and pupillary reflex in the rat.

Authors: S Daniotti; P Del Soldato
Journal: Br J Pharmacol Date: 1984-06 Impact factor: 8.739

7. Characterization of the muscarine receptors involved in the modulation of serotonin release from the vascularly perfused small intestine of guinea pig.

Authors: H Schwörer; K Racké; H Kilbinger
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1989-03 Impact factor: 3.000