Literature DB >> 6895696

A comparison of adriamycin and mAMSA in vitro: cell lethality and SCE studies.

C West, I J Stratford, N Barrass, E Smith.   

Abstract

We have compared the actions of ADM and mAMSA in Chinese hamster V79 cells in vitro, using cell survival and sister-chromatid exchange as end-points. Equimolar concentrations of ADM and mAMSA show similar toxicities to exponentially growing cells, and both drugs are less effective in killing chronically hypoxic and plateau-phase cells. Cytotoxicity to thermotolerant cells (41 degrees C for 16 h previously) shows little difference from that for exponential cells. Pre-treating cells with misonidazole under hypoxic conditions reduces the toxicity of both ADM and mAMSA. In addition, an ADM-resistant Chinese hamster cell line, 77A-177, was cross-resistant to mAMSA. Finally, low equimolar sub-toxic doses of both drugs were found to cause similar increases in the levels of sister-chromatid exchanges in V79 cells. These results reveal no major difference in activity between ADM and mAMSA in vitro.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6895696      PMCID： PMC2010861          DOI： 10.1038/bjc.1981.278

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  28 in total

1.  Adriamycin resistance and radiation response.

Authors:  J A Belli; J R Harris
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-08       Impact factor: 7.038

2.  Kinetic response of cultured Chinese hamster cells to treatment with 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide-HCl.

Authors:  R A Tobey; L L Deaven; M S Oka
Journal:  J Natl Cancer Inst       Date:  1978-05       Impact factor: 13.506

3.  Simultaneous detection of chromosomal aberrations and sister-chromatid exchanges: experience with DNA intercalating agents.

Authors:  A S Raj; J A Heddle
Journal:  Mutat Res       Date:  1980-07       Impact factor: 2.433

4.  The relation between chemically induced sister-chromatid exchanges and chromatid breakage.

Authors:  S M Galloway; S Wolff
Journal:  Mutat Res       Date:  1979-07       Impact factor: 2.433

5.  Cell-cycle-specific chromosome damage following treatment of cultured Chinese hamster cells with 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide-HCl.

Authors:  L L Deaven; M S Oka; R A Tobey
Journal:  J Natl Cancer Inst       Date:  1978-05       Impact factor: 13.506

6.  Lethality of nogalamycin, nogalamycin analogs, and adriamycin to cells in different cell cycle phases.

Authors:  B K Bhuyan; C L Blowers; K D Shugars
Journal:  Cancer Res       Date:  1980-10       Impact factor: 12.701

7.  Adriamycin uptake in V79 and adriamycin resistant Chinese hamster cells.

Authors:  J R Harris; N Timberlake; P Henson; P Schimke; J A Belli
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-08       Impact factor: 7.038

8.  Phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in metastatic breast cancer.

Authors:  S S Legha; G R Blumenschein; A U Buzdar; G N Hortobagyi; G P Bodey
Journal:  Cancer Treat Rep       Date:  1979 Nov-Dec

9.  Phase II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in patients with metastatic hypernephroma.

Authors:  R J Schneider; T M Woodcock; A Yagoda
Journal:  Cancer Treat Rep       Date:  1980-01

10.  Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.

Authors:  E Smith; I J Stratford; G E Adams
Journal:  Br J Cancer       Date:  1980-10       Impact factor: 7.640
View more
  9 in total

1.  Induction of sister chromatid exchanges by inhibitors of topoisomerases.

Authors:  M Lim; L F Liu; D Jacobson-Kram; J R Williams
Journal:  Cell Biol Toxicol       Date:  1986-12       Impact factor: 6.691

2.  Effectiveness of AMSA alone or in combination with radiation on murine fibrosarcoma pulmonary nodules.

Authors:  D J Grdina; S Jones; N Hunter
Journal:  Clin Exp Metastasis       Date:  1984 Jul-Sep       Impact factor: 5.150

3.  Influence of scheduling on therapeutic and toxic effect of AMSA in Lewis lung carcinoma.

Authors:  C Greco; G Zupi; G Badaracco
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

4.  Human cytomegalovirus induces expression of cellular topoisomerase II.

Authors:  J D Benson; E S Huang
Journal:  J Virol       Date:  1990-01       Impact factor: 5.103

5.  Two specific topoisomerase II inhibitors prevent replication of human cytomegalovirus DNA: an implied role in replication of the viral genome.

Authors:  J D Benson; E S Huang
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103

6.  Loss of viability and induction of DNA damage in human leukemic myeloblasts and lymphocytes by m-AMSA.

Authors:  L W Brox; A Belch; A Ng; E Pollock
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

7.  A comparison of adriamycin and mAMSA. II. Studies with V79 and human tumour multicellular spheroids.

Authors:  C M West; I J Stratford
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

8.  Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.

Authors:  Janine T Erler; Christopher J Cawthorne; Kaye J Williams; Marianne Koritzinsky; Bradley G Wouters; Clare Wilson; Crispin Miller; Costas Demonacos; Ian J Stratford; Caroline Dive
Journal:  Mol Cell Biol       Date:  2004-04       Impact factor: 4.272

9.  Misonidazole protects mouse tumour and normal tissues from the toxicity of oral CCNU.

Authors:  F Y Lee; P Workman
Journal:  Br J Cancer       Date:  1985-01       Impact factor: 7.640
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.