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Literature DB >> 689366

Induced resistance to 6-methylpurine and cycloheximide in tetrahymena. I. Germ line mutants of T. thermophila.

Abstract

Two new mutant lines of Tetrahymena thermophila (T. pyriformis, syngen 1), each conferring resistance to a different agent, are described. Resistance to cycloheximide and 6-methylpurine are each determined by dominant genes, ChxA2 and Mpr; the traits show phenotypic assortment. The method used to select these mutations, the critical importance of backcrossing to wild type following mutagenesis, and the utility of these marker genes in further mutagenic selection schemes and studies of the sexual cycle of Tetrahymena are noted.

Entities: Chemical Species

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Year: 1978 PMID： 689366 PMCID： PMC1213861

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

9 in total

1. Multiple inhibition by 6-methylpurine.

Authors: V C DEWEY; M R HEINRICH; D G MARKEES; G W KIDDER
Journal: Biochem Pharmacol Date: 1960-06 Impact factor: 5.858

2. The Genetics of the H Serotype System in Variety 1 of Tetrahymena Pyriformis.

Authors: D L Nanney; J M Dubert
Journal: Genetics Date: 1960-10 Impact factor: 4.562

3. Characterization of the species of the Tetrahymena pyriformis complex.

Authors: D L Nanney; J W McCoy
Journal: Trans Am Microsc Soc Date: 1976-10

4. Costimulation in Tetrahymena pyriformis: a developmental interaction between specially prepared cells.

Authors: P J Bruns; R F Palestine
Journal: Dev Biol Date: 1975-01 Impact factor: 3.582

5. A cycloheximide-resistant mutant of Tetrahymena pyriformis.

Authors: C T Roberts; E Orias
Journal: Exp Cell Res Date: 1973-10 Impact factor: 3.905

6. Pair formation in tetrahymena pyriformis, an inducible developmental system.

Authors: P J Bruns; T B Brussard
Journal: J Exp Zool Date: 1974-06

7. Isolation of homozygous mutants after induced self-fertilization in Tetrahymena.

Authors: P J Bruns; T B Brussard; A B Kavka
Journal: Proc Natl Acad Sci U S A Date: 1976-09 Impact factor: 11.205

8. Genetics of cycloheximide resistance in Tetrahymena.

Authors: L K Bleyman; P J Bruns
Journal: Genetics Date: 1977-10 Impact factor: 4.562

9. Induced resistance to 6-methylpurine and cycloheximide in Tetrahymena. II. Variation within vegetative cultures of micronucleate T. thermophila and amicronucleate T. pyriformis.

Authors: B C Byrne
Journal: Genetics Date: 1978-08 Impact factor: 4.562

9 in total

17 in total

7. Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome.

Authors: G M Kapler; E Orias; E H Blackburn
Journal: Genetics Date: 1994-06 Impact factor: 4.562

Induced resistance to 6-methylpurine and cycloheximide in tetrahymena. I. Germ line mutants of T. thermophila.

1. Multiple inhibition by 6-methylpurine.

2. The Genetics of the H Serotype System in Variety 1 of Tetrahymena Pyriformis.

3. Characterization of the species of the Tetrahymena pyriformis complex.

4. Costimulation in Tetrahymena pyriformis: a developmental interaction between specially prepared cells.

5. A cycloheximide-resistant mutant of Tetrahymena pyriformis.

6. Pair formation in tetrahymena pyriformis, an inducible developmental system.

7. Isolation of homozygous mutants after induced self-fertilization in Tetrahymena.

8. Genetics of cycloheximide resistance in Tetrahymena.

9. Induced resistance to 6-methylpurine and cycloheximide in Tetrahymena. II. Variation within vegetative cultures of micronucleate T. thermophila and amicronucleate T. pyriformis.

1. Pronuclear fusion failure: an alternate conjugational pathway in Tetrahymena thermophila, induced by vinblastine.

2. A drug-resistant mutation in the ribosomal DNA of Tetrahymena.

3. Tetrahymena in the laboratory: strain resources, methods for culture, maintenance, and storage.

4. The replication advantage of a free linear rRNA gene is restored by somatic recombination in Tetrahymena thermophila.

5. Properties of the translocatable tetracycline-resistance element Tn10 in Escherichia coli and bacteriophage lambda.

6. Molecular evidence for somatic recombination in the ribosomal DNA of Tetrahymena thermophila.

7. Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome.

8. Selection and characterization of a glucokinase-deficient mutant of Tetrahymena thermophila.

9. Chromosome-designated mutation selection in Tetrahymena thermophila.

10. Isolation and genetic characterization of a mutation affecting ribosomal resistance to cycloheximide in Tetrahymena.