Literature DB >> 6890721

Activation of plasminogen by tissue activator is increased specifically in the presence of certain soluble fibrin(ogen) fragments.

J H Verheijen, W Nieuwenhuizen, G Wijngaards.   

Abstract

Tissue activator-mediated plasminogen activation is potentiated both by fibrin and by some soluble fibrin(ogen) fragments. The potentiating effect of the different fragments decreases in the order fibrin monomer greater than D-dimer greater than Y greater than D EGTA greater than Dcate greater than X. Fibrinogen and the fragments Ecate, E EGTA and E fibrin have almost no effect. The existence of a fibrin polymer is apparently not a prerequisite for this potentiating effect. The plasminogen activation by various urokinase preparations is not potentiated by fibrin and fibrin(ogen) fragments.

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Year:  1982        PMID： 6890721     DOI： 10.1016/0049-3848(82)90055-x

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  8 in total

Review 1.  Studies on rat mammary adenocarcinomas: a model for metastasis.

Authors:  I A Ramshaw; P Badenoch-Jones
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

2.  The sequence A alpha-(148-160) in fibrin, but not in fibrinogen, is accessible to monoclonal antibodies.

Authors:  W J Schielen; M Voskuilen; G I Tesser; W Nieuwenhuizen
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

3.  The interaction of streptokinase.plasminogen activator complex, tissue-type plasminogen activator, urokinase and their acylated derivatives with fibrin and cyanogen bromide digest of fibrinogen. Relationship to fibrinolytic potency in vitro.

Authors:  R Cassels; R Fears; R A Smith
Journal:  Biochem J       Date:  1987-10-15       Impact factor: 3.857

4.  Kinetic studies on the interaction of streptokinase and other plasminogen activators with plasminogen and fibrin.

Authors:  R Fears; M J Hibbs; R A Smith
Journal:  Biochem J       Date:  1985-07-15       Impact factor: 3.857

5.  Localization in the fibrinogen gamma-chain of a new site that is involved in the acceleration of the tissue-type plasminogen activator-catalysed activation of plasminogen.

Authors:  O Yonekawa; M Voskuilen; W Nieuwenhuizen
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

6.  Soluble fibrin degradation products potentiate tissue plasminogen activator-induced fibrinogen proteolysis.

Authors:  J I Weitz; B Leslie; J Ginsberg
Journal:  J Clin Invest       Date:  1991-03       Impact factor: 14.808

7.  Structural requirements of position A alpha-157 in fibrinogen for the fibrin-induced rate enhancement of the activation of plasminogen by tissue-type plasminogen activator.

Authors:  J G Schielen; H P Adams; M Voskuilen; G J Tesser; W Nieuwenhuizen
Journal:  Biochem J       Date:  1991-06-15       Impact factor: 3.857

8.  A comparative study of the promotion of tissue plasminogen activator and pro-urokinase-induced plasminogen activation by fragments D and E-2 of fibrin.

Authors:  J N Liu; V Gurewich
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808
  8 in total

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