Literature DB >> 4041182

Kinetic studies on the interaction of streptokinase and other plasminogen activators with plasminogen and fibrin.

R Fears, M J Hibbs, R A Smith.   

Abstract

The activation of Lys-plasminogen to plasmin by streptokinase was promoted by soluble fibrin such that Km was decreased and Vmax. increased. Enhancement was also observed when Glu-plasminogen was the substrate and was shared by the preformed streptokinase-plasminogen activator complex, indicating that the stimulation was not exerted primarily on the rate of active site formation.

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Year:  1985        PMID： 4041182      PMCID： PMC1145091          DOI： 10.1042/bj2290555

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  Steady state kinetics of activation of human and bovine plasminogens by streptokinase and its equimolar complexes with various activated forms of human plasminogen.

Authors:  R C Wohl; L Summaria; L Arzadon; K C Robbins
Journal:  J Biol Chem       Date:  1978-03-10       Impact factor: 5.157

2.  Activator activities of the transient forms of the human plasminogen-streptokinase complex during its proteolytic conversion to the stable activator complex.

Authors:  G Markus; J L Evers; G H Hobika
Journal:  J Biol Chem       Date:  1976-11-10       Impact factor: 5.157

3.  The mechanism of activation of human plasminogen by streptokinase.

Authors:  D K McClintock; P H Bell
Journal:  Biochem Biophys Res Commun       Date:  1971-05-07       Impact factor: 3.575

4.  Augmentation of streptokinase activator activity by fibrinogen or fibrin.

Authors:  S M Camiolo; G Markus; J L Evers; G H Hobika
Journal:  Thromb Res       Date:  1980-03-01       Impact factor: 3.944

5.  Studies on SK-potentiator of plasminogen in human plasma.

Authors:  A Takada; Y Takada
Journal:  Thromb Res       Date:  1978-09       Impact factor: 3.944

6.  Kinetics of activation of human plasminogen by different activator species at pH 7.4 and 37 degrees C.

Authors:  R C Wohl; L Summaria; K C Robbins
Journal:  J Biol Chem       Date:  1980-03-10       Impact factor: 5.157

7.  Fibrinogen-fibrin conversion. The mechanism of fibrin-polymer formation in solution.

Authors:  G F Smith
Journal:  Biochem J       Date:  1980-01-01       Impact factor: 3.857

8.  On the specific interaction between the lysine-binding sites in plasmin and complementary sites in alpha2-antiplasmin and in fibrinogen.

Authors:  B Wiman; H R Lijnen; D Collen
Journal:  Biochim Biophys Acta       Date:  1979-07-25

9.  Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapy.

Authors:  R A Smith; R J Dupe; P D English; J Green
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

10.  The evaluation of plasmin and streptokinase activator complexes in a new rabbit model of venous thrombosis.

Authors:  R J Dupe; P D English; R A Smith; J Green
Journal:  Thromb Haemost       Date:  1981-08-28       Impact factor: 5.249
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  7 in total

1.  Kinetic studies on the effect of heparin and fibrin on plasminogen activators.

Authors:  R Fears
Journal:  Biochem J       Date:  1988-01-01       Impact factor: 3.857

Review 2.  Binding of plasminogen activators to fibrin: characterization and pharmacological consequences.

Authors:  R Fears
Journal:  Biochem J       Date:  1989-07-15       Impact factor: 3.857

3.  The effect of heparin and fibrin on the enzymatic efficiencies of thrombolytics in vitro.

Authors:  R Fears
Journal:  Drugs       Date:  1987       Impact factor: 9.546

4.  The interaction of streptokinase.plasminogen activator complex, tissue-type plasminogen activator, urokinase and their acylated derivatives with fibrin and cyanogen bromide digest of fibrinogen. Relationship to fibrinolytic potency in vitro.

Authors:  R Cassels; R Fears; R A Smith
Journal:  Biochem J       Date:  1987-10-15       Impact factor: 3.857

5.  Kinetic studies on novel plasminogen activators. Demonstration of fibrin enhancement for hybrid enzymes comprising the A-chain of plasmin (Lys-78) and B-chain of tissue-type plasminogen activator (Ile-276) or urokinase (Ile-159).

Authors:  R Fears; I Dodd; H Ferres; J H Robinson
Journal:  Biochem J       Date:  1990-03-15       Impact factor: 3.857

6.  Effects of extracellular DNA on plasminogen activation and fibrinolysis.

Authors:  Andrey A Komissarov; Galina Florova; Steven Idell
Journal:  J Biol Chem       Date:  2011-10-05       Impact factor: 5.157

7.  Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

Authors:  Galina Florova; Ali O Azghani; Sophia Karandashova; Chris Schaefer; Serge V Yarovoi; Paul J Declerck; Douglas B Cines; Steven Idell; Andrey A Komissarov
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2017-08-31       Impact factor: 5.464
  7 in total

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