Literature DB >> 6890626

Genotoxicity studies of di(2-ethylhexyl)phthalate and its metabolites in CHO cells.

B J Phillips, T E James, S D Gangolli.   

Abstract

The widely used plasticizer di(2-ethylhexyl)phthalate (DEHP), its hydrolysis products mono(2-ethylhexyl)phthalate (MEHP) and 2-ethylhexanol, and also phthalic acid have been tested for clastogenic activity in cultured Chinese hamster ovary (CHO) cells. Only MEHP was found to cause chromosome damage. MEHP was without effect in the SCE and HGPRT mutation test in CHO cells. The clastogenicity of MEHP suggests a role for this compound in the observed carcinogenicity of DEHP and its positive effect in the dominant lethal assay.

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Year:  1982        PMID： 6890626     DOI： 10.1016/0165-1218(82)90139-2

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  9 in total

1.  Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA).

Authors:  A R Malcolm; L J Mills
Journal:  Cell Biol Toxicol       Date:  1989-06       Impact factor: 6.691

Review 2.  Comprehensive review of 2-ethyl-1-hexanol as an indoor air pollutant.

Authors:  Takanari Wakayama; Yuki Ito; Kiyoshi Sakai; Mio Miyake; Eiji Shibata; Hiroyuki Ohno; Michihiro Kamijima
Journal:  J Occup Health       Date:  2019-01       Impact factor: 2.708

3.  Assessment of Cytotoxic, Genotoxic, and Oxidative Stress of Dibutyl Phthalate on Cultured Bovine Peripheral Lymphocytes.

Authors:  Muhammad Muddassir Ali; Taha Sahar; Sehrish Firyal; Muhammad Ijaz; Khalid Abdul Majeed; Furqan Awan; Memoona Adil; Haroon Akbar; Muhammad Imran Rashid; İbrahim Hakki Ciğerci
Journal:  Oxid Med Cell Longev       Date:  2022-03-24       Impact factor: 6.543

4.  Carcinogenic potential of phthalic acid esters and related compounds: structure-activity relationships.

Authors:  W M Kluwe
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031

5.  Genetic toxicology of phthalate esters: mutagenic and other genotoxic effects.

Authors:  G R Douglas; A P Hugenholtz; D H Blakey
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031

6.  Chemical industry voluntary test program for phthalate esters: health effects studies.

Authors:  B Astill; E Barber; A Lington; E Moran; A Mulholland; E Robinson; B Scheider
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031

7.  Studies on the genetic effects of phthalic acid esters on cells in culture.

Authors:  B J Phillips; D Anderson; S D Gangolli
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031

Review 8.  Toxicological characterization of phthalic Acid.

Authors:  Du Yeon Bang; In Kyung Lee; Byung-Mu Lee
Journal:  Toxicol Res       Date:  2011-12

9.  Genotoxicity Evaluation of Irrigative Wastewater from Shijiazhuang City in China.

Authors:  Xuehui Liu; Longmei Tang; Lixue Yang; Xiaolin Zhang; Liqin Wang; Fengxue Yu; Yi Liu; Qing Chen; Dianwu Liu
Journal:  PLoS One       Date:  2015-12-14       Impact factor: 3.240
  9 in total

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