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Literature DB >> 6885064

Isoelectric focusing with immobilized pH gradients for the analysis of transferrin (Tf) subtypes and variants.

A Görg, J Weser, R Westermeier, W Postel, S Weidinger, W Patutschnick, H Cleve.

Abstract

The human serum transferrin (Tf) system was analyzed by isoelectric focusing (IEF) with immobilized pH gradients. For the demonstration of the genetic variability the Fe1-Tf region was chosen. The pH range suitable for analysis of the Tf system was pH 5.20 to pH 5.75. The phenotypes of the common six TfC subtypes are described. No further heterogeneity among TfC1, TfC2, and TfC3 was noted. Aslo presented are the phenotypes of the TfC6 subtype, and of three different TfB and three different TfD variants. IEF with immobilized pH gradients appears to be a suitable method for the analysis of the inherited transferrin polymorphism.

Entities: Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6885064 DOI： 10.1007/bf00279397

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

20 in total

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Authors: O SMITHIES
Journal: Nature Date: 1957-12-28 Impact factor: 49.962

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Authors: A Görg; W Postel; R Westermeier; E Gianazza; P G Righetti
Journal: J Biochem Biophys Methods Date: 1980-11

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Authors: H Walter; H Strodtmann; M Hilling; I P Singh; M K Bhasin; P Veerraju
Journal: Hum Hered Date: 1981 Impact factor: 0.444

5. A new procedure for the determination of transferrin C (Tf C) subtypes by isoelectric focusing. Existence of two additional alleles, Tf C4 and Tf C5.

Authors: J Constans; P Kühnl; M Viau; W Spielmann
Journal: Hum Genet Date: 1980 Impact factor: 4.132

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Authors: H Stibler; G Beckman; C Silkström
Journal: Hum Hered Date: 1979 Impact factor: 0.444

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Authors: S Weidinger; F Schwarzfischer; H Cleve
Journal: Z Rechtsmed Date: 1980

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Authors: P Kühnl; W Spielmann
Journal: Hum Genet Date: 1978-07-12 Impact factor: 4.132

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Authors: P Kühnl; W Spielmann; W Weber
Journal: Hum Genet Date: 1979-01-19 Impact factor: 4.132

10. Group-specific component (Gc) and transferrin (Tf) subtypes ascertained by isoelectric focusing. A simple nonimmunological staining procedure for Gc.

Authors: B Hoste
Journal: Hum Genet Date: 1979 Impact factor: 4.132

5 in total

1. Detection of cerebrospinal fluid leakage by isoelectric focusing on polyacrylamide gels with silver staining using the PhastSystem.

Authors: K Blennow; P Fredman
Journal: Acta Neurochir (Wien) Date: 1995 Impact factor: 2.216

2. A new alpha 1-antitrypsin allele PI Poki: isoelectric focusing with immobilized pH gradients as a tool for identification for PI variants.

Authors: I Yuasa; K Okada
Journal: Hum Genet Date: 1985 Impact factor: 4.132