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Literature DB >> 6884768

Evidence for balancing selection at HLA.

Abstract

HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.

Mesh：

Substances：
HLA Antigens

Year: 1983 PMID： 6884768 PMCID： PMC1202087

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

8 in total

1. An analysis of multi-allelic data.

Authors: G A Watterson
Journal: Genetics Date: 1978-01 Impact factor: 4.562

2. The homozygosity test of neutrality.

Authors: G A Watterson
Journal: Genetics Date: 1978-02 Impact factor: 4.562

3. The effect of a selected locus on linked neutral loci.

Authors: G Thomson
Journal: Genetics Date: 1977-04 Impact factor: 4.562

Review 4. Population genetics theory in relation to the neutralist-selectionist controversy.

Authors: W J Ewens
Journal: Adv Hum Genet Date: 1977

Review 5. Evolutionary significance of the HL-A system.

Authors: W F Bodmer
Journal: Nature Date: 1972-05-19 Impact factor: 49.962

6. Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.

Authors: J A López de Castro; J L Strominger; D M Strong; H T Orr
Journal: Proc Natl Acad Sci U S A Date: 1982-06 Impact factor: 11.205

7. The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events.

Authors: E H Weiss; A Mellor; L Golden; K Fahrner; E Simpson; J Hurst; R A Flavell
Journal: Nature Date: 1983-02-24 Impact factor: 49.962

8. A review of theoretical aspects of HLA and disease associations.

Authors: G Thomson
Journal: Theor Popul Biol Date: 1981-10 Impact factor: 1.570

8 in total

102 in total

1. Symbiont survival and host-symbiont disequilibria under differential vertical transmission.

Authors: M S Sánchez; J Arnold; M A Asmussen
Journal: Genetics Date: 2000-03 Impact factor: 4.562

2. Evolution of HLA class II molecules: Allelic and amino acid site variability across populations.

Authors: H Salamon; W Klitz; S Easteal; X Gao; H A Erlich; M Fernandez-Viña; E A Trachtenberg; S K McWeeney; M P Nelson; G Thomson
Journal: Genetics Date: 1999-05 Impact factor: 4.562

3. HLA-DR polymorphism in a Senegalese Mandenka population: DNA oligotyping and population genetics of DRB1 specificities.

Authors: J M Tiercy; A Sanchez-Mazas; L Excoffier; X Shi-Isaac; M Jeannet; B Mach; A Langaney
Journal: Am J Hum Genet Date: 1992-09 Impact factor: 11.025

4. Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication.

Authors: K M Kiemnec-Tyburczy; J Q Richmond; A E Savage; K R Lips; K R Zamudio
Journal: Heredity (Edinb) Date: 2012-05-02 Impact factor: 3.821

5. Major histocompatibility complex differentiation in Sacramento River chinook salmon.

Authors: T J Kim; K M Parker; P W Hedrick
Journal: Genetics Date: 1999-03 Impact factor: 4.562

6. Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes.

Authors: P W Hedrick; T S Whittam; P Parham
Journal: Proc Natl Acad Sci U S A Date: 1991-07-01 Impact factor: 11.205

7. Heterogeneity of dN/dS Ratios at the Classical HLA Class I Genes over Divergence Time and Across the Allelic Phylogeny.

Authors: Bárbara Domingues Bitarello; Rodrigo dos Santos Francisco; Diogo Meyer
Journal: J Mol Evol Date: 2015-11-14 Impact factor: 2.395