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Literature DB >> 863244

The effect of a selected locus on linked neutral loci.

Abstract

The effects produced on linked neutral loci as a selected locus evolves towards its equilibrium value are considered. Significant effects on the neutral loci arise if the recombination fraction between the neutral and selected loci is smaller than the order of magnitude of the selective differences at the selected locus. The effect on gene frequencies at the neutral loci, that is, the hitchhiking effect, is determined, as well as the linkage disequilibrium generated by this hitchhiking effect. One of the more important findings is that significant disequilibrium can be generated between two neutral loci by the evolution of a linked selected locus. Consideration is given to the problem of determining how the effect of selection operating in natural populations can be detected, the question of the establishment of inversions in populations, and also to the nonequilibrium properties of populations.

Mesh：

Year: 1977 PMID： 863244 PMCID： PMC1213655

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

15 in total

1. Numerical studies on two-loci selection models with general viabilities.

Authors: S Karlin; D Carmelli
Journal: Theor Popul Biol Date: 1975-06 Impact factor: 1.570

2. General two-locus selection models: some objectives, results and interpretations.

Authors: S Karlin
Journal: Theor Popul Biol Date: 1975-06 Impact factor: 1.570

3. The evolution of mimicry: a problem in ecology and genetics.

Authors: P M SHEPPARD
Journal: Cold Spring Harb Symp Quant Biol Date: 1959

4. Enzyme polymorphisms in man.

Authors: H Harris
Journal: Proc R Soc Lond B Biol Sci Date: 1966-03-22

5. The effect of population subdivision on two loci without selection.

Authors: M W Feldman; F B Christiansen
Journal: Genet Res Date: 1974-10 Impact factor: 1.588

Review 6. Evolutionary significance of the HL-A system.

Authors: W F Bodmer
Journal: Nature Date: 1972-05-19 Impact factor: 49.962

7. Selection in complex genetic systems. I. The symmetric equilibria of the three-locus symmetric viability model.

Authors: M W Feldman; I Franklin; G J Thomson
Journal: Genetics Date: 1974-01 Impact factor: 4.562

8. A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura.

Authors: J L Hubby; R C Lewontin
Journal: Genetics Date: 1966-08 Impact factor: 4.562

9. Associations of alleles of the esterase-1 locus with gene arrangements of the left arm of the second chromosome in Drosophila robusta.

Authors: S Prakash; M Levitan
Journal: Genetics Date: 1973-10 Impact factor: 4.562

10. Linkage disequilibrium causing selection at a neutral locus in pooled Tribolium populations.

Authors: P Stam
Journal: Heredity (Edinb) Date: 1975-02 Impact factor: 3.821

50 in total

1. Sojourn times and substitution rate at overdominant and linked neutral loci.

Authors: J Ohashi; K Tokunaga
Journal: Genetics Date: 2000-06 Impact factor: 4.562

2. Hitchhiking under positive Darwinian selection.

Authors: J C Fay; C I Wu
Journal: Genetics Date: 2000-07 Impact factor: 4.562

3. Distribution of nonrandom associations between pairs of protein loci along the third chromosome of Drosophila melanogaster.

Authors: Carlos Zapata; Concepción Núñez; Teresa Velasco
Journal: Genetics Date: 2002-08 Impact factor: 4.562

7. Two types of genetic differentiation in the evolution of sibling species of the spiny rats from genus Proechimys native to Upper Amazonia.

Authors: A N Milishnikov
Journal: Dokl Biol Sci Date: 2006 May-Jun