Literature DB >> 6884489

Analgesic activity of certain tripeptide-beta-phenethylamide analogs.

C Kamei, M Mio, K Tasaka.   

Abstract

Studies of the analgesic effect of tripeptide-beta-phenethylamides are described, and their structure-activity relationship is discussed. SD-25, which has a methyl group at R2, and a hydroxymethyl group at R3 of beta-phenethylamide, was the most potent one of the 8 analogs tested.

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Year:  1983        PMID： 6884489     DOI： 10.1007/bf01989784

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Potent analgesic activity of the enkephalin-like tetrapeptide H-Tyr-D-Ala-Gly-Phe-NH2.

Authors:  W H McGregor; L Stein; J D Belluzzi
Journal:  Life Sci       Date:  1978-10-02       Impact factor: 5.037

2.  A simplified method of evaluating dose-effect experiments.

Authors:  J T LITCHFIELD; F WILCOXON
Journal:  J Pharmacol Exp Ther       Date:  1949-06       Impact factor: 4.030

3.  A synthetic enkephalin analogue with prolonged parenteral and oral analgesic activity.

Authors:  D Roemer; H H Buescher; R C Hill; J Pless; W Bauer; F Cardinaux; A Closse; D Hauser; R Huguenin
Journal:  Nature       Date:  1977-08-11       Impact factor: 49.962

4.  Structure activity relationship of orally active enkephalin analogues as analgesics.

Authors:  D Roemer; J Pless
Journal:  Life Sci       Date:  1979-02-12       Impact factor: 5.037

5.  A superactive antinociceptive pentapeptide, (D-Met2, Pro5)-enkephalinamide.

Authors:  S Bajusz; A Z Rónai; J I Székely; L Gráf; Z Dunai-Kovács; I Berzétei
Journal:  FEBS Lett       Date:  1977-04-01       Impact factor: 4.124

Review 6.  Structure-activity relationships of enkephalin-like peptides.

Authors:  J S Morley
Journal:  Annu Rev Pharmacol Toxicol       Date:  1980       Impact factor: 13.820

7.  Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Authors:  J Hughes; T W Smith; H W Kosterlitz; L A Fothergill; B A Morgan; H R Morris
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962
  7 in total

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