Is increased cholesterol excretion the link between low serum cholesterol and colon cancer?

The data from several different patient groups consuming high-fat, high-cholesterol diets suggest that decreased serum cholesterol may be linked with increased cholesterol excretion. Since cholesterol or its degradation products have been implicated in the pathogenesis of colon cancer, an inverse relationship between serum and biliary cholesterol levels could explain the statistical relationship between low serum cholesterol and colon cancer observed in recent prospective studies.