Literature DB >> 6874878

Computer-based virus sensitivity assay and neutralization method. Applications for herpesviruses.

B Wahren, P Wahren, J Harmenberg, V A Sundqvist.   

Abstract

A method for computerized analysis of the antiviral efficiency of drugs and immunoglobulins was developed. The sensitivities of herpes simplex virus (HSV), cytomegalovirus (CMV) and varicella-zoster virus (VZV) to antiviral drugs were determined. A new type of neutralization assay could be performed rapidly and accurately with HSV and CMV. Combining immunological methods for herpesvirus antigen detection with a computerized analysis permitted rapid, sensitive measurement of drug sensitivities, comparison of antiviral activities at various virus concentrations and selection of potent neutralizing antisera.

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Year:  1983        PMID： 6874878     DOI： 10.1016/0166-0934(83)90042-3

Source DB:  PubMed          Journal:  J Virol Methods        ISSN： 0166-0934            Impact factor:   2.014


  8 in total

1.  Activity of the cytomegalovirus genome in the presence of PPi analogs.

Authors:  B Wahren; U Rudén; H Gadler; B Oberg; B Eriksson
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

2.  Acyclic guanosine analogs as substrates for varicella-zoster virus thymidine kinase.

Authors:  A R Karlström; C F Källander; G Abele; A Larsson
Journal:  Antimicrob Agents Chemother       Date:  1986-01       Impact factor: 5.191

3.  Comparative methods for detection of thymidine kinase-deficient herpes simplex virus type 1 strains.

Authors:  J Harmenberg; V A Sundqvist; H Gadler; B Levén; G Brännström; B Wahren
Journal:  Antimicrob Agents Chemother       Date:  1986-10       Impact factor: 5.191

4.  Acyclic guanosine analogs as inhibitors of human cytomegalovirus.

Authors:  B Wahren; A Larsson; U Rudén; A Sundqvist; E Sølver
Journal:  Antimicrob Agents Chemother       Date:  1987-02       Impact factor: 5.191

5.  Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture.

Authors:  G Abele; A Karlström; J Harmenberg; S Shigeta; A Larsson; B Lindborg; B Wahren
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

6.  Characterization of human monoclonal antibodies directed against the pp65-kD matrix antigen of human cytomegalovirus.

Authors:  M Ohlin; V A Sundqvist; G Gilljam; U Rudén; F O Gombert; B Wahren; C A Borrebaeck
Journal:  Clin Exp Immunol       Date:  1991-06       Impact factor: 4.330

7.  Antiviral activities of guanosine analogs in guinea pig embryonic fibroblasts.

Authors:  J Harmenberg; K Stenberg
Journal:  Antimicrob Agents Chemother       Date:  1988-10       Impact factor: 5.191

8.  Pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys of (R,S)-9-[4-hydroxy-2-(hydroxymethyl) butyl]guanine, an anti-varicella-zoster virus drug.

Authors:  D M Lake-Bakaar; G Abele; B Lindborg; K F Soike; R Datema
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191
  8 in total

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