Literature DB >> 6872617

Penetration of metronidazole and tinidazole into the aqueous humor in man.

J Mattila, K Nerdrum, H Rouhiainen, P Männistö, E Tuovinen, U Lamminsivu.   

Abstract

500 mg of metronidazole or tinidazole were given as a 20-min infusion each to 10 patients who were hospitalized for elective cataract extraction. Metronidazole and tinidazole concentrations in aqueous humor were 5.2 +/- (SE) 0.5 and 5.3 +/- 0.7 micrograms/ml, respectively, 20-70 min after the end of the infusion. Aqueous humor/serum concentration ratios were 0.38 and 0.47 on the average for metronidazole and tinidazole, respectively.

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Year:  1983        PMID： 6872617     DOI： 10.1159/000238196

Source DB:  PubMed          Journal:  Chemotherapy        ISSN： 0009-3157            Impact factor:   2.544


  3 in total

1.  Concentrations of metronidazole and tinidazole in female reproductive organs after a single intravenous infusion and after repeated oral administration.

Authors:  P Männistö; M Karhunen; J Mattila; O Koskela; A M Suikkari; P Heinonen; R Tuimala; H Haataja
Journal:  Infection       Date:  1984 May-Jun       Impact factor: 3.553

2.  Concentrations of metronidazole and tinidazole in male genital tissues.

Authors:  J Viitanen; H Haataja; P T Männistö
Journal:  Antimicrob Agents Chemother       Date:  1985-12       Impact factor: 5.191

3.  Placental transfer of metronidazole and tinidazole in early human pregnancy after a single infusion.

Authors:  M Karhunen
Journal:  Br J Clin Pharmacol       Date:  1984-08       Impact factor: 4.335
  3 in total

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