| Literature DB >> 6487467 |
Abstract
Concentrations of metronidazole and tinidazole were analysed in mother's serum, placental tissue and foetal tissue after a single intravenous infusion of 500 mg of either drug in 21 patients who underwent a first trimester legal abortion. At the time of the evacuation (60 min from the start of the infusion) the concentrations of metronidazole and tinidazole in serum were 13.6 +/- 0.6 micrograms/ml and 13.2 +/- 0.4 micrograms/ml, respectively. In foetal tissue the concentrations of metronidazole and tinidazole reached 66% and 58%, and in placental tissue 26% and 37%, of the respective serum values.Entities:
Keywords: Abortion, Induced; Age Factors; Anatomy; Bacterial And Fungal Diseases; Biology; Body Weight; Diseases; Embryo; Evaluation; Examinations And Diagnoses; Family Planning; Fertility Control, Postconception; Fetal Membranes; Fetus; Histology; Infections; Laboratory Examinations And Diagnoses; Laboratory Procedures; Physiology; Population Characteristics; Pregnancy; Reproduction; Treatment--administraction and dosage
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Year: 1984 PMID： 6487467 PMCID： PMC1463524 DOI： 10.1111/j.1365-2125.1984.tb02465.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335