| Literature DB >> 6871890 |
E G Mimnaugh, M A Trush, T E Gram.
Abstract
Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.Entities:
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Year: 1983 PMID： 6871890
Source DB: PubMed Journal: Cancer Treat Rep ISSN： 0361-5960