Literature DB >> 6870806

Transport of myo-inositol into endoneurial preparations of sciatic nerve from normal and streptozotocin-diabetic rats.

K R Gillon, J N Hawthorne.   

Abstract

myo-Inositol transport by a viable rat sciatic-nerve preparation is described. Such 'endoneurial' nerve preparations accumulated myo-inositol by an energy-dependent saturable system. Streptozotocin-diabetes reduced myo-inositol transport into sciatic nerve by approx. 40%. Elevated medium glucose concentration reduced myo-inositol transport into control nerves to a similar extent. Fructose and sorbitol did not inhibit myo-inositol transport. Inclusion of an aldose reductase inhibitor in the medium counteracted the reduced myo-inositol transport caused by elevated glucose concentration. The importance of these results to the problem of diabetic neuropathy is discussed.

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Year:  1983        PMID： 6870806      PMCID： PMC1154289          DOI： 10.1042/bj2100775

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

1.  Phosphoinositide metabolism in rat superior cervical ganglion, vagus and phrenic nerve: effects of electrical stimulation and various blocking agents.

Authors:  G L White; H U Schellhase; J N Hawthorne
Journal:  J Neurochem       Date:  1974-01       Impact factor: 5.372

2.  Polyol pathway in aorta: regulation by hormones.

Authors:  R S Clements; A D Morrison; A I Winegrad
Journal:  Science       Date:  1969-11-21       Impact factor: 47.728

3.  The sorbitol pathway. Enzyme localization and content in normal and diabetic nerve and cord.

Authors:  K H Gabbay; J B O'Sullivan
Journal:  Diabetes       Date:  1968-05       Impact factor: 9.461

4.  Phosphoinositides and other phospholipids in sympathetic ganglia and nerve trunks of rats. Effects of neuronal activity and inositol analogs ( - and -hexachlorocyclohexane (lindane)) on ( 32 P)-labelling, synaptic transmission and axonal conduction.

Authors:  G L White; M G Larrabee
Journal:  J Neurochem       Date:  1973-03       Impact factor: 5.372

5.  D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis.

Authors:  F Eisenberg
Journal:  J Biol Chem       Date:  1967-04-10       Impact factor: 5.157

6.  Inositol changes in nerve and lens of galactose fed rats.

Authors:  M A Stewart; M M Kurien; W R Sherman; E V Cotlier
Journal:  J Neurochem       Date:  1968-09       Impact factor: 5.372

7.  Changes in myo-inositol permeability in the lens due to cataractous conditions.

Authors:  R M Broekhuyse
Journal:  Biochim Biophys Acta       Date:  1968-09-17

8.  Active transport of myo-inositol and its relation to the sugar transport system in hamster small intestine.

Authors:  W F Caspary; R K Crane
Journal:  Biochim Biophys Acta       Date:  1970-04-21

9.  Energy- and sodium-dependent uptake of inositol by kidney cortex slices.

Authors:  G Hauser
Journal:  Biochem Biophys Res Commun       Date:  1965-06-09       Impact factor: 3.575

10.  Levels of myo-inositol in normal and degenerating peripheral nerve.

Authors:  H Kusama; M A Stewart
Journal:  J Neurochem       Date:  1970-03       Impact factor: 5.372
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  19 in total

1.  A myo-inositol pool utilized for phosphatidylinositol synthesis is depleted in sciatic nerve from rats with streptozotocin-induced diabetes.

Authors:  X Zhu; J Eichberg
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

Review 2.  Inositol trisphosphate and diacylglycerol as second messengers.

Authors:  M J Berridge
Journal:  Biochem J       Date:  1984-06-01       Impact factor: 3.857

3.  The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells.

Authors:  I H Batty; A Michie; M Fennel; C P Downes
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

4.  Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats.

Authors:  J H Mayer; D R Tomlinson
Journal:  Diabetologia       Date:  1983-11       Impact factor: 10.122

5.  Mechanism of glucose-induced (Na+, K+)-ATPase inhibition in aortic wall of rabbits.

Authors:  D A Simmons; A I Winegrad
Journal:  Diabetologia       Date:  1989-07       Impact factor: 10.122

6.  Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

Authors:  P A Craven; F R DeRubertis
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

7.  Active transport of myo-inositol in rat pancreatic islets.

Authors:  T J Biden; C B Wollheim
Journal:  Biochem J       Date:  1986-06-15       Impact factor: 3.857

8.  Osmotic regulation of myo-inositol uptake in primary astrocyte cultures.

Authors:  R E Isaacks; A S Bender; C Y Kim; N M Prieto; M D Norenberg
Journal:  Neurochem Res       Date:  1994-03       Impact factor: 3.996

9.  Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.

Authors:  K R Gillon; J N Hawthorne; D R Tomlinson
Journal:  Diabetologia       Date:  1983-10       Impact factor: 10.122

10.  D-3-deoxy-3-substituted myo-inositol analogues as inhibitors of cell growth.

Authors:  G Powis; I A Aksoy; D C Melder; S Aksoy; H Eichinger; A H Fauq; A P Kozikowski
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333
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