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Literature DB >> 6869126

Inhibition of histamine biosynthesis and gastric function in the rat: effect on pentagastrin-induced gastric acid secretion.

Abstract

A very simple and rapid method to measure gastric acid secretion in the conscious unoperated fasted rat is reported. Antisecretory activity of cimetidine and hypersecretory activity of pentagastrin are detected by this procedure. Pentagastrin induces gastric acid secretion and causes an increase by 2-fold in histidine decarboxylase activity. There is a delay between the increase of gastric acid output and the appearance of histidine decarboxylase activity. Co-administration of monofluoromethyl histidine, a specific irreversible inhibitor of histidine decarboxylase, does not modify the peak response to pentagastrin but shortens the duration of stimulation. We suggest from this data that histamine biosynthesis is needed for maintenance of elevated gastric acid secretion.

Entities: Chemical Gene Species

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Year: 1983 PMID： 6869126 DOI： 10.1007/bf01967342

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

15 in total

1. Increased sensitivity of the enzymatic isotopic assay of histamine: measurement of histamine in plasma and serum.

Authors: R E Shaff; M A Beaven
Journal: Anal Biochem Date: 1979-04-15 Impact factor: 3.365

2. A quantitative method for measuring spontaneous gastric secretion in the rat.

Authors: H SHAY; D C SUN; M GRUENSTEIN
Journal: Gastroenterology Date: 1954-06 Impact factor: 22.682

3. The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.

Authors: M J Jung; B Lippert; B W Metcalf; P J Schechter; P Böhlen; A Sjoerdsma
Journal: J Neurochem Date: 1977-04 Impact factor: 5.372

4. Isotopic microassay of histamine, histidine, histidine decarboxylase and histamine methyltransferase in brain tissue.

Authors: K M Taylor; S H Snyder
Journal: J Neurochem Date: 1972-05 Impact factor: 5.372

5. Effect of pentagastrin and feeding on gastric histidine decarboxylase activity in the antrectomized rat.

Authors: R Håkanson; G Liedberg
Journal: Eur J Pharmacol Date: 1972-04 Impact factor: 4.432

6. Selective inhibitors of biosynthesis of aminergic neurotransmitters.

Authors: J Kollonitsch; L M Perkins; A A Patchett; G A Doldouras; S Marburg; D E Duggan; A L Maycock; S D Aster
Journal: Nature Date: 1978-08-31 Impact factor: 49.962

7. Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies.

Authors: M Garbarg; G Barbin; E Rodergas; J C Schwartz
Journal: J Neurochem Date: 1980-11 Impact factor: 5.372

Review 3. Histidine decarboxylase inhibition: a novel approach towards the development of an effective and safe gastric anti-ulcer drug.

Authors: N S Parmar; G Hennings; O P Gulati
Journal: Agents Actions Date: 1984-12

4. Differential effects of calcium channel antagonists on histamine and pentagastrin-stimulated gastric acid secretion in the rat.

Authors: M Bouclier; M Spedding
Journal: Agents Actions Date: 1985-09

4 in total

Inhibition of histamine biosynthesis and gastric function in the rat: effect on pentagastrin-induced gastric acid secretion.

1. Increased sensitivity of the enzymatic isotopic assay of histamine: measurement of histamine in plasma and serum.

2. A quantitative method for measuring spontaneous gastric secretion in the rat.

3. The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.

4. Isotopic microassay of histamine, histidine, histidine decarboxylase and histamine methyltransferase in brain tissue.

5. Effect of pentagastrin and feeding on gastric histidine decarboxylase activity in the antrectomized rat.

6. Selective inhibitors of biosynthesis of aminergic neurotransmitters.

7. Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies.

8. alpha-Fluoromethyl histidine. Inhibition of histidine decarboxylase in pylorus ligated rat.

9. Histamine-release in rat gastric mucosa by pentagastrin.

10. Integration of biochemical functions of different cells of rat gastric mucosa for hydrochloric acid secretion.

1. Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations.

2. Effects of a mast cell stabiliser (FPL 52694) on human gastric secretion.

Review 3. Histidine decarboxylase inhibition: a novel approach towards the development of an effective and safe gastric anti-ulcer drug.

4. Differential effects of calcium channel antagonists on histamine and pentagastrin-stimulated gastric acid secretion in the rat.