Literature DB >> 6860344

alpha-Fluoromethyl histidine. Inhibition of histidine decarboxylase in pylorus ligated rat.

M Bouclier, M J Jung, F Gerhart.   

Abstract

alpha-Fluoromethyl histidine is an irreversible inhibitor of histidine decarboxylase. The injection of a single dose to pyloric-ligated rats inhibits gastric mucosal histidine decarboxylase in a dose-dependent manner but does not modify histamine content and gastric acid secretion even at the highest dose used. Administration of cimetidine increases histidine decarboxylase activity, decreases histamine level in gastric mucosa and inhibits gastric acid secretion. The co-administration of alpha-fluoromethyl histidine blocks the augmentation in enzyme activity, maintains lowered histamine level and prolongs the antisecretory action of cimetidine.

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Year:  1983        PMID： 6860344     DOI： 10.1016/0006-2952(83)90326-x

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  7 in total

1.  Involvement of histamine in endothelium-dependent relaxation of mesenteric lymphatic vessels.

Authors:  Irina Tsoy Nizamutdinova; Daisuke Maejima; Takashi Nagai; Eric Bridenbaugh; Sangeetha Thangaswamy; Victor Chatterjee; Cynthia J Meininger; Anatoliy A Gashev
Journal:  Microcirculation       Date:  2014-10       Impact factor: 2.628

2.  Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations.

Authors:  M Bouclier; M J Jung; F Gerhart
Journal:  Experientia       Date:  1983-11-15

3.  Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells.

Authors:  Sarit Pal; Olga Y Gasheva; David C Zawieja; Cynthia J Meininger; Anatoliy A Gashev
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2020-01-08       Impact factor: 3.619

4.  Effect of omeprazole-evoked hypergastrinemia on ultrastructure of enterochromaffin-like cells in the stomach of portacaval-shunted rats.

Authors:  D Chen; R Håkanson; F Sundler
Journal:  Cell Tissue Res       Date:  1993-04       Impact factor: 5.249

5.  Enterochromaffin-like cells in the rat stomach: effect of alpha-fluoromethylhistidine-evoked histamine depletion. A chemical, histochemical and electron-microscopic study.

Authors:  K Andersson; D Chen; R Håkanson; H Mattsson; F Sundler
Journal:  Cell Tissue Res       Date:  1992-10       Impact factor: 5.249

6.  Long-term depletion of histamine in guinea-pigs by administration of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase; effect on the sensitivity of histamine receptors.

Authors:  H Fukuda; K Maeyama; Y Ito; T Watanabe; H Wada
Journal:  Agents Actions       Date:  1988-06

7.  Inhibition of histamine biosynthesis and gastric function in the rat: effect on pentagastrin-induced gastric acid secretion.

Authors:  M Bouclier; M Jung; F Gerhart
Journal:  Agents Actions       Date:  1983-04
  7 in total

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